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• W2945458022 abstract "Imaging biomarkers can be used to screen participants for Alzheimer's disease clinical trials. To test the predictive values in clinical progression of neuropathology change (amyloid-PET) or brain metabolism as neurodegeneration biomarker ([18F]FDG-PET), we evaluated data from N = 268 healthy controls and N = 519 mild cognitive impairment subjects. Despite being a significant risk factor, amyloid positivity was not associated with clinical progression in the majority (≥60%) of subjects. Notably, a negative [18F]FDG-PET scan at baseline strongly predicted clinical stability with high negative predictive values (>0.80) for both groups. We suggest [18F]FDG-PET brain metabolism or other neurodegeneration measures should be coupled to amyloid-PET to exclude clinically stable individuals from clinical trials." @default.
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• W2945458022 date "2019-05-24" @default.
• W2945458022 modified "2023-10-05" @default.
• W2945458022 title "Predicting long‐term clinical stability in amyloid‐positive subjects by <scp>FDG</scp> ‐ <scp>PET</scp>" @default.
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• W2945458022 doi "https://doi.org/10.1002/acn3.782" @default.
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