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• W2945459119 endingPage "1057" @default.
• W2945459119 startingPage "1051" @default.
• W2945459119 abstract "Long noncoding RNAs (lncRNAs), a group of transcripts without protein coding potential, have been reported to play critical roles in progression of hepatocellular carcinoma (HCC). However, the biological role of DDX11-AS1 in HCC is not clear. In this study, we found that DDX11-AS1 expression was dramatically higher in HCC tissues and cell lines. Higher DDX11-AS1 expression predicted poor overall survival of patients. Functionally, the proliferation, cell cycle progression, migration, and invasion of HCC cells were inhibited by DDX11-AS1 silencing, while promoted by ectopic expression of DDX11-AS1. RNA immunoprecipitation (RIP) and chromatin immunoprecipitation (ChIP) assays validated that DDX11-AS1 suppressed LATS2 expression by interacting with EZH2 and DNMT1 in HCC cells. Knockdown of DDX11-AS1 increased the mRNA and protein levels of LATS2. Overexpression of LATS2 abolished the promotive effect of DDX11-AS1 on cell growth and invasion. Besides, DDX11-AS1 promoted tumor formation in vivo. The mRNA levels of LATS2 were markedly decreased in tumor tissues and negatively correlated with DDX11-AS1 expression. Taken together, our data indicated that DDX11-AS1 may be a novel oncogene in hepatocarcinogenesis by repressing LATS2, providing a potential therapeutic target for HCC treatment." @default.
• W2945459119 created "2019-05-29" @default.
• W2945459119 creator A5015436826 @default.
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• W2945459119 date "2019-07-01" @default.
• W2945459119 modified "2023-10-15" @default.
• W2945459119 title "Long noncoding RNA DDX11-AS1 epigenetically represses LATS2 by interacting with EZH2 and DNMT1 in hepatocellular carcinoma" @default.
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• W2945459119 doi "https://doi.org/10.1016/j.bbrc.2019.05.042" @default.
• W2945459119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31097223" @default.
• W2945459119 hasPublicationYear "2019" @default.
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