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- W2945461161 abstract "Carcinoembryonic antigen (CEA) is a surface glycoprotein expressed in human epithelial cells and is released from their surface, especially during colorectal cancer. Frequently, colorectal cancer is accompanied by inflammation, where tumor-infiltrating neutrophils play an important role. CEA was also found to be a strong chemotactic agent for neutrophils. The purpose of this study was to find out if CEA can enhance neutrophil priming and activation. Primed neutrophils were activated by N-formyl-methionyl-leucyl-phenylalanine (formyl-MLP) and the resulting oxidative burst was measured luminometrically. Unexpectedly, in vitro priming of neutrophils by CEA, alone or preceded by LPS, inhibited subsequent activation of these cells by formyl-MLP. CEA may have anti-inflammatory properties in vivo." @default.
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- W2945461161 date "2015-01-01" @default.
- W2945461161 modified "2023-10-18" @default.
- W2945461161 title "Carcinoembryonic antigen inhibits neutrophil activation by N-formyl-methionyl-leucyl-phenylalanine" @default.
- W2945461161 doi "https://doi.org/10.32604/biocell.2015.39.001" @default.
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