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- W2945464525 abstract "Abstract To reduce the size of paracetamol crystals for enhancement of the dissolution property, a crystallization process involving sonication to supersaturated paracetamol solution obtained by rapid cooling was proposed. It was found that when polyvinylpyrrolidone, a surface-active agent that exerts an inhibitory effect on coalescence of cavitation bubbles generated by sonication, was added, the kinetic parameter of classical nucleation theory increased remarkably. The average size of the paracetamol crystals obtained using the proposed process, which inhibited agglomeration, was about 3 μm with a narrow size distribution, where these particles are much smaller than the agglomerates (40–50 μm) obtained by agitation alone." @default.
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- W2945464525 date "2019-09-01" @default.
- W2945464525 modified "2023-09-26" @default.
- W2945464525 title "Effect of a surface-active agent on nucleation kinetics in ultrasound-assisted crystallization of paracetamol" @default.
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- W2945464525 doi "https://doi.org/10.1016/j.jiec.2019.05.009" @default.
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