Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945467054> ?p ?o ?g. }
- W2945467054 endingPage "7" @default.
- W2945467054 startingPage "1" @default.
- W2945467054 abstract "Heat can trigger testicular damage and impair fertility. Leydig cells produce testosterone in response to stimulation by luteinizing hormone (LH), which induces Ca2+ entry and K+ efflux through ion channels in their plasma membrane. Considering that mechanisms coordinating the Leydig cell responses to hyperthermic stress remain unclear; the present study analyzed the effects of heat stress (HS, 43°C, 15 min) and inhibition of Hsp90 on T-type calcium currents and voltage-dependent potassium currents (VKC) in mice Leydig cells. Results show that HS reduced the VKC steady state currents at +80 mV (45.3%) and maximum conductance (71.5%), as well as increased the activation time constant (31.7%) and the voltage for which half the channels are open (30%). Hsp90 inhibition did not change the VKC currents. T-type calcium currents were not affected by HS or Hsp90 inhibition. In conclusion, HS can slow the activation, reduce the currents and voltage dependence of the VKC, suggesting a possible role of these currents in the response to hyperthermic stress in Leydig cells." @default.
- W2945467054 created "2019-05-29" @default.
- W2945467054 creator A5007209686 @default.
- W2945467054 creator A5026636972 @default.
- W2945467054 creator A5028179516 @default.
- W2945467054 creator A5032520357 @default.
- W2945467054 creator A5050601906 @default.
- W2945467054 creator A5069132540 @default.
- W2945467054 date "2019-08-01" @default.
- W2945467054 modified "2023-09-27" @default.
- W2945467054 title "Effect of heat stress and Hsp90 inhibition on T-type calcium currents and voltage-dependent potassium currents in leydig cells" @default.
- W2945467054 cites W1674496011 @default.
- W2945467054 cites W1900522001 @default.
- W2945467054 cites W1971933823 @default.
- W2945467054 cites W1982826698 @default.
- W2945467054 cites W1985570771 @default.
- W2945467054 cites W1993904291 @default.
- W2945467054 cites W2005198836 @default.
- W2945467054 cites W2010840797 @default.
- W2945467054 cites W2017569474 @default.
- W2945467054 cites W2020524199 @default.
- W2945467054 cites W2031199214 @default.
- W2945467054 cites W2038731679 @default.
- W2945467054 cites W2051654992 @default.
- W2945467054 cites W2056198198 @default.
- W2945467054 cites W2063013379 @default.
- W2945467054 cites W2072925339 @default.
- W2945467054 cites W2077363486 @default.
- W2945467054 cites W2077754831 @default.
- W2945467054 cites W2079258871 @default.
- W2945467054 cites W2082490296 @default.
- W2945467054 cites W2085048839 @default.
- W2945467054 cites W2086349306 @default.
- W2945467054 cites W2095018271 @default.
- W2945467054 cites W2096738517 @default.
- W2945467054 cites W2116408740 @default.
- W2945467054 cites W2117018035 @default.
- W2945467054 cites W2126695143 @default.
- W2945467054 cites W2167444324 @default.
- W2945467054 cites W2171654757 @default.
- W2945467054 cites W2207258055 @default.
- W2945467054 cites W2273080084 @default.
- W2945467054 cites W2273760516 @default.
- W2945467054 cites W2323894395 @default.
- W2945467054 cites W2619294570 @default.
- W2945467054 cites W2792330108 @default.
- W2945467054 doi "https://doi.org/10.1016/j.jtherbio.2019.05.022" @default.
- W2945467054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31466741" @default.
- W2945467054 hasPublicationYear "2019" @default.
- W2945467054 type Work @default.
- W2945467054 sameAs 2945467054 @default.
- W2945467054 citedByCount "4" @default.
- W2945467054 countsByYear W29454670542021 @default.
- W2945467054 countsByYear W29454670542022 @default.
- W2945467054 countsByYear W29454670542023 @default.
- W2945467054 crossrefType "journal-article" @default.
- W2945467054 hasAuthorship W2945467054A5007209686 @default.
- W2945467054 hasAuthorship W2945467054A5026636972 @default.
- W2945467054 hasAuthorship W2945467054A5028179516 @default.
- W2945467054 hasAuthorship W2945467054A5032520357 @default.
- W2945467054 hasAuthorship W2945467054A5050601906 @default.
- W2945467054 hasAuthorship W2945467054A5069132540 @default.
- W2945467054 hasConcept C12554922 @default.
- W2945467054 hasConcept C126322002 @default.
- W2945467054 hasConcept C134018914 @default.
- W2945467054 hasConcept C185592680 @default.
- W2945467054 hasConcept C24998067 @default.
- W2945467054 hasConcept C2777736315 @default.
- W2945467054 hasConcept C2778575703 @default.
- W2945467054 hasConcept C2779279991 @default.
- W2945467054 hasConcept C519063684 @default.
- W2945467054 hasConcept C71315377 @default.
- W2945467054 hasConcept C71924100 @default.
- W2945467054 hasConcept C83743174 @default.
- W2945467054 hasConcept C86803240 @default.
- W2945467054 hasConceptScore W2945467054C12554922 @default.
- W2945467054 hasConceptScore W2945467054C126322002 @default.
- W2945467054 hasConceptScore W2945467054C134018914 @default.
- W2945467054 hasConceptScore W2945467054C185592680 @default.
- W2945467054 hasConceptScore W2945467054C24998067 @default.
- W2945467054 hasConceptScore W2945467054C2777736315 @default.
- W2945467054 hasConceptScore W2945467054C2778575703 @default.
- W2945467054 hasConceptScore W2945467054C2779279991 @default.
- W2945467054 hasConceptScore W2945467054C519063684 @default.
- W2945467054 hasConceptScore W2945467054C71315377 @default.
- W2945467054 hasConceptScore W2945467054C71924100 @default.
- W2945467054 hasConceptScore W2945467054C83743174 @default.
- W2945467054 hasConceptScore W2945467054C86803240 @default.
- W2945467054 hasLocation W29454670541 @default.
- W2945467054 hasLocation W29454670542 @default.
- W2945467054 hasOpenAccess W2945467054 @default.
- W2945467054 hasPrimaryLocation W29454670541 @default.
- W2945467054 hasRelatedWork W1988486434 @default.
- W2945467054 hasRelatedWork W2012502375 @default.
- W2945467054 hasRelatedWork W2047880909 @default.
- W2945467054 hasRelatedWork W2057000165 @default.
- W2945467054 hasRelatedWork W2064034534 @default.
- W2945467054 hasRelatedWork W2086384643 @default.