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- W2945481870 abstract "A major challenge in the application of cytotoxic anti-cancer drugs is their general lack of selectivity, which often leads to systematic toxicity due to their inability to discriminate between malignant and healthy cells. A particularly promising target for selective targeting are the folate receptors (FR) that are often over-expressed on cancer cells. Here, we report on a conjugate of the pentadentate nitrogen ligand N4Py to folic acid, via a cleavable disulphide linker, which shows selective cytotoxicity against folate receptor expressing cancer cells." @default.
- W2945481870 created "2019-05-29" @default.
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- W2945481870 date "2019-08-01" @default.
- W2945481870 modified "2023-10-02" @default.
- W2945481870 title "Folic acid conjugates of a bleomycin mimic for selective targeting of folate receptor positive cancer cells" @default.
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- W2945481870 doi "https://doi.org/10.1016/j.bmcl.2019.05.047" @default.
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