Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945484570> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W2945484570 endingPage "S751" @default.
- W2945484570 startingPage "S750" @default.
- W2945484570 abstract "Tacrolimus is the cornerstone of immunosuppressive therapy after kidney transplantation (KT), but its use is complicated by a narrow therapeutic index and high inter- and intra-patient pharmacokinetic variability. There are three available oral formulations of tacrolimus: immediate-release tacrolimus (IR-Tac), extended-release tacrolimus (ER-Tac) and a MeltDose® (LCPT) formulation, the latter favoring a prolonged drug release and increased bioavailability. The time-concentration curves of these formulations are different. Compared with IR-Tac and ER-Tac, LCPT has a relatively flat pharmacokinetic profile with less fluctuation between trough and peak exposures, and a delayed peak concentration. This translates to a more stable delivery of tacrolimus and may alleviate the risk of underexposure and allograft rejection or overexposure and toxicity. The once-daily formulation of both ER-TAC and LCPT may also offer a potential advantage on patient adherence. Fast metabolizers of tacrolimus, the elderly, and human leukocyte antigen-sensitized patients are at risk of poorer outcomes after KT, possibly associated with a different exhibited pharmacokinetics of tacrolimus or different requirements in terms of exposure. Simple, practical strategies are needed to identify patients at risk of suboptimal KT outcomes and those who would benefit from a more proactively personalized approach to tacrolimus treatment. This review aims to increase awareness of the link between the pharmacokinetics of oral tacrolimus formulations and the clinical needs of patients after KT, particularly among those who have clinically significant pharmacokinetic variation of tacrolimus." @default.
- W2945484570 created "2019-05-29" @default.
- W2945484570 creator A5030171732 @default.
- W2945484570 date "2019-06-01" @default.
- W2945484570 modified "2023-09-25" @default.
- W2945484570 title "A comprehensive framework for test evaluation under the new IVD regulation" @default.
- W2945484570 doi "https://doi.org/10.1016/j.cca.2019.03.1466" @default.
- W2945484570 hasPublicationYear "2019" @default.
- W2945484570 type Work @default.
- W2945484570 sameAs 2945484570 @default.
- W2945484570 citedByCount "0" @default.
- W2945484570 crossrefType "journal-article" @default.
- W2945484570 hasAuthorship W2945484570A5030171732 @default.
- W2945484570 hasConcept C112705442 @default.
- W2945484570 hasConcept C126322002 @default.
- W2945484570 hasConcept C126894567 @default.
- W2945484570 hasConcept C181389837 @default.
- W2945484570 hasConcept C19831878 @default.
- W2945484570 hasConcept C2780035454 @default.
- W2945484570 hasConcept C2909675724 @default.
- W2945484570 hasConcept C2911091166 @default.
- W2945484570 hasConcept C31785415 @default.
- W2945484570 hasConcept C42404028 @default.
- W2945484570 hasConcept C71924100 @default.
- W2945484570 hasConcept C98274493 @default.
- W2945484570 hasConceptScore W2945484570C112705442 @default.
- W2945484570 hasConceptScore W2945484570C126322002 @default.
- W2945484570 hasConceptScore W2945484570C126894567 @default.
- W2945484570 hasConceptScore W2945484570C181389837 @default.
- W2945484570 hasConceptScore W2945484570C19831878 @default.
- W2945484570 hasConceptScore W2945484570C2780035454 @default.
- W2945484570 hasConceptScore W2945484570C2909675724 @default.
- W2945484570 hasConceptScore W2945484570C2911091166 @default.
- W2945484570 hasConceptScore W2945484570C31785415 @default.
- W2945484570 hasConceptScore W2945484570C42404028 @default.
- W2945484570 hasConceptScore W2945484570C71924100 @default.
- W2945484570 hasConceptScore W2945484570C98274493 @default.
- W2945484570 hasLocation W29454845701 @default.
- W2945484570 hasOpenAccess W2945484570 @default.
- W2945484570 hasPrimaryLocation W29454845701 @default.
- W2945484570 hasRelatedWork W1558880863 @default.
- W2945484570 hasRelatedWork W2017999632 @default.
- W2945484570 hasRelatedWork W2045224469 @default.
- W2945484570 hasRelatedWork W2075280372 @default.
- W2945484570 hasRelatedWork W2169439801 @default.
- W2945484570 hasRelatedWork W2354680669 @default.
- W2945484570 hasRelatedWork W2359939078 @default.
- W2945484570 hasRelatedWork W2369726129 @default.
- W2945484570 hasRelatedWork W3024440267 @default.
- W2945484570 hasRelatedWork W3204382284 @default.
- W2945484570 hasVolume "493" @default.
- W2945484570 isParatext "false" @default.
- W2945484570 isRetracted "false" @default.
- W2945484570 magId "2945484570" @default.
- W2945484570 workType "article" @default.