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- W2945491437 endingPage "158461" @default.
- W2945491437 startingPage "158461" @default.
- W2945491437 abstract "Structural lipids are mostly synthesized in the endoplasmic reticulum (ER), from which they are actively transported to the membranes of other organelles. Lipids can leave the ER through vesicular trafficking or non-vesicular lipid transfer and, curiously, both processes can be regulated either by the transported lipid cargos themselves or by different secondary lipid species. For most structural lipids, transport out of the ER membrane is a key regulatory component controlling their synthesis. Distribution of the lipids between the two leaflets of the ER bilayer or between the ER and other membranes is also critical for maintaining the unique membrane properties of each cellular organelle. How cells integrate these processes within the ER depends on fine spatial segregation of the molecular components and intricate metabolic channeling, both of which we are only beginning to understand. This review will summarize some of these complex processes and attempt to identify the organizing principles that start to emerge. This article is part of a Special Issue entitled Endoplasmic reticulum platforms for lipid dynamics edited by Shamshad Cockcroft and Christopher Stefan." @default.
- W2945491437 created "2019-05-29" @default.
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- W2945491437 creator A5021531343 @default.
- W2945491437 creator A5050743363 @default.
- W2945491437 date "2020-01-01" @default.
- W2945491437 modified "2023-10-03" @default.
- W2945491437 title "Lipid synthesis and transport are coupled to regulate membrane lipid dynamics in the endoplasmic reticulum" @default.
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- W2945491437 doi "https://doi.org/10.1016/j.bbalip.2019.05.005" @default.
- W2945491437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6858525" @default.
- W2945491437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31108203" @default.
- W2945491437 hasPublicationYear "2020" @default.
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