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- W2945492210 abstract "FEIBA causes in vitro a concentration-dependent shortening of APTT of hemophilic plasma containing antibody to factor VIII. Since the potency of preparation is based on this in vitro test, it was of interest to examine whether a dose-dependent shortening of APTT and clotting time is also observed under in vivo conditions, APTT, whole blood glass clotting time and reaction time (=R value of thrombelastogramm) were determined before and 30 to 60 min. after 91 infusions of FE IBA (dose range 6 - 100 U/kg) to 10 hemophiliacs with antibody. Although there was a considerable scatter, a significant inverse correlation between the dose of FE IBA and postinfusion APTT and R-value was observedThe dose response curve was, however, rather flat. No significant correlation existed between FE IBA dose and glass clotting time. The effect of FE IBA on the APTT was not dependent on the antibody level, both, in vitro and in vivo. There was only a slight variant ot the effect among different patients, but a marked variation among different lots ot tne preparation, FE IBA seems to have a weak clinical hemostatic effect. A clear relationship between dose and clinical effect could not be established but it appears that doses higher than 50 U/kg are not more effective than smaller doses." @default.
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- W2945492210 date "1979-01-01" @default.
- W2945492210 modified "2023-09-23" @default.
- W2945492210 title "Effect of in vivo Administration of FeibaR on Clotting Tests: Dose-Response Relationship" @default.
- W2945492210 doi "https://doi.org/10.1055/s-0039-1684739" @default.
- W2945492210 hasPublicationYear "1979" @default.
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