FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945492989> ?p ?o ?g. }

• W2945492989 endingPage "233" @default.
• W2945492989 startingPage "233" @default.
• W2945492989 abstract "Tuberculosis is a major health problem and remains one of the main causes of mortality. In recent years, there has been an increased interest in the pulmonary delivery of antibiotics to treat tuberculosis. Isoniazid is one of these antibiotics. In this study, we aimed to characterize isoniazid and formulate it into a dry powder for pulmonary administration with little or no excipient, and for use in the disposable Twincer® inhaler. Isoniazid was jet milled and spray dried with and without the excipient l-leucine. Physiochemical characterization showed that isoniazid has a low Tg of −3.99 ± 0.18 °C and starts to sublimate around 80 °C. Milling isoniazid with and without excipients did not result in a suitable formulation, as it resulted in a low and highly variable fine particle fraction. Spray drying pure isoniazid resulted in particles too large for pulmonary administration. The addition of 5% l-leucine resulted in a fraction <5 µm = 89.61% ± 1.77% from spray drying, which dispersed well from the Twincer®. However, storage stability was poor at higher relative humidity, which likely results from dissolution-crystallization. Therefore, follow up research is needed to further optimize this spray dried formulation." @default.
• W2945492989 created "2019-05-29" @default.
• W2945492989 creator A5008287871 @default.
• W2945492989 creator A5021333179 @default.
• W2945492989 creator A5081913054 @default.
• W2945492989 creator A5091581887 @default.
• W2945492989 date "2019-05-13" @default.
• W2945492989 modified "2023-09-29" @default.
• W2945492989 title "Characterization and Formulation of Isoniazid for High-Dose Dry Powder Inhalation" @default.
• W2945492989 cites W1865318914 @default.
• W2945492989 cites W1968930061 @default.
• W2945492989 cites W1975163730 @default.
• W2945492989 cites W1985484350 @default.
• W2945492989 cites W1996648654 @default.
• W2945492989 cites W1999671466 @default.
• W2945492989 cites W2012613859 @default.
• W2945492989 cites W2012658698 @default.
• W2945492989 cites W2014314762 @default.
• W2945492989 cites W2018417584 @default.
• W2945492989 cites W2022558739 @default.
• W2945492989 cites W2022921705 @default.
• W2945492989 cites W2031505647 @default.
• W2945492989 cites W2037699568 @default.
• W2945492989 cites W2061952624 @default.
• W2945492989 cites W2073090477 @default.
• W2945492989 cites W2078036942 @default.
• W2945492989 cites W2089129742 @default.
• W2945492989 cites W2090509393 @default.
• W2945492989 cites W2100164793 @default.
• W2945492989 cites W2112135623 @default.
• W2945492989 cites W2127971692 @default.
• W2945492989 cites W2137398998 @default.
• W2945492989 cites W2142070022 @default.
• W2945492989 cites W2155875390 @default.
• W2945492989 cites W2194053553 @default.
• W2945492989 cites W2296732157 @default.
• W2945492989 cites W2344588517 @default.
• W2945492989 cites W2404758810 @default.
• W2945492989 cites W2516060412 @default.
• W2945492989 cites W2558118358 @default.
• W2945492989 cites W2558649339 @default.
• W2945492989 cites W2589978917 @default.
• W2945492989 cites W2810784135 @default.
• W2945492989 cites W416331074 @default.
• W2945492989 cites W644591398 @default.
• W2945492989 doi "https://doi.org/10.3390/pharmaceutics11050233" @default.
• W2945492989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6572553" @default.
• W2945492989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31086107" @default.
• W2945492989 hasPublicationYear "2019" @default.
• W2945492989 type Work @default.
• W2945492989 sameAs 2945492989 @default.
• W2945492989 citedByCount "20" @default.
• W2945492989 countsByYear W29454929892019 @default.
• W2945492989 countsByYear W29454929892020 @default.
• W2945492989 countsByYear W29454929892021 @default.
• W2945492989 countsByYear W29454929892022 @default.
• W2945492989 countsByYear W29454929892023 @default.
• W2945492989 crossrefType "journal-article" @default.
• W2945492989 hasAuthorship W2945492989A5008287871 @default.
• W2945492989 hasAuthorship W2945492989A5021333179 @default.
• W2945492989 hasAuthorship W2945492989A5081913054 @default.
• W2945492989 hasAuthorship W2945492989A5091581887 @default.
• W2945492989 hasBestOaLocation W29454929891 @default.
• W2945492989 hasConcept C126322002 @default.
• W2945492989 hasConcept C13965031 @default.
• W2945492989 hasConcept C14029885 @default.
• W2945492989 hasConcept C142724271 @default.
• W2945492989 hasConcept C147789679 @default.
• W2945492989 hasConcept C178790620 @default.
• W2945492989 hasConcept C185592680 @default.
• W2945492989 hasConcept C187530423 @default.
• W2945492989 hasConcept C192562407 @default.
• W2945492989 hasConcept C2776042228 @default.
• W2945492989 hasConcept C2776954882 @default.
• W2945492989 hasConcept C2776967927 @default.
• W2945492989 hasConcept C2777239854 @default.
• W2945492989 hasConcept C2777419714 @default.
• W2945492989 hasConcept C2779587474 @default.
• W2945492989 hasConcept C2780035454 @default.
• W2945492989 hasConcept C2780261241 @default.
• W2945492989 hasConcept C2781069245 @default.
• W2945492989 hasConcept C2781430271 @default.
• W2945492989 hasConcept C42219234 @default.
• W2945492989 hasConcept C43617362 @default.
• W2945492989 hasConcept C71924100 @default.
• W2945492989 hasConcept C88380143 @default.
• W2945492989 hasConcept C98274493 @default.
• W2945492989 hasConceptScore W2945492989C126322002 @default.
• W2945492989 hasConceptScore W2945492989C13965031 @default.
• W2945492989 hasConceptScore W2945492989C14029885 @default.
• W2945492989 hasConceptScore W2945492989C142724271 @default.
• W2945492989 hasConceptScore W2945492989C147789679 @default.
• W2945492989 hasConceptScore W2945492989C178790620 @default.
• W2945492989 hasConceptScore W2945492989C185592680 @default.
• W2945492989 hasConceptScore W2945492989C187530423 @default.
• W2945492989 hasConceptScore W2945492989C192562407 @default.
• W2945492989 hasConceptScore W2945492989C2776042228 @default.
• W2945492989 hasConceptScore W2945492989C2776954882 @default.

• next