Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945493658> ?p ?o ?g. }
Showing items 1 to 47 of
47
with 100 items per page.
- W2945493658 abstract "Endogenous mechanisms of reactive oxygen (ROS) and nitrogen species production and of antioxidant defense systems in tumor cells are analyzed. Increased ROS production is an important regulator of metabolic changes in these cells: enhanced proliferation, apoptosis inhibition, resistance to hypoxia and to cytostatics (doxorubicin, carboplatin, cisplatin, etc.). The most active ROS sources in tumor cells are mitochondria, NAD(P)H oxidases and peroxisomes, which synthesize O2 • – and H2O2. In mitochondria, the superoxide anion radical is generated mainly by complexes I and III; membrane NAD(P)H oxidases Nox1, Nox2, Nox3, and Nox5 produce O2 • –, Nox4, and dual oxidases DUOX-1, DUOX-2 – mainly H2O2. Increasing ROS stationary concentration activates endogenous antioxidant defense mechanisms, such as redox-dependent antioxidant respons(iv)e element system Keap1/Nrf2/ARE and autophagy, which allows tumor cells to survive under oxidative stress and may underlie resistance to radio- and chemotherapy. The possibilities of tumor cell redox balance regulation by antioxidants with targeted action and by specific inhibitors of ROS enzymatic production are discussed." @default.
- W2945493658 created "2019-05-29" @default.
- W2945493658 date "2019-01-01" @default.
- W2945493658 modified "2023-10-17" @default.
- W2945493658 title "FEATURES OF REDOX REGULATION IN TUMOR CELLS" @default.
- W2945493658 doi "https://doi.org/10.15372/ssmj20190202" @default.
- W2945493658 hasPublicationYear "2019" @default.
- W2945493658 type Work @default.
- W2945493658 sameAs 2945493658 @default.
- W2945493658 citedByCount "4" @default.
- W2945493658 countsByYear W29454936582020 @default.
- W2945493658 countsByYear W29454936582022 @default.
- W2945493658 crossrefType "journal-article" @default.
- W2945493658 hasBestOaLocation W29454936581 @default.
- W2945493658 hasConcept C12554922 @default.
- W2945493658 hasConcept C178790620 @default.
- W2945493658 hasConcept C185592680 @default.
- W2945493658 hasConcept C502942594 @default.
- W2945493658 hasConcept C55904794 @default.
- W2945493658 hasConcept C86803240 @default.
- W2945493658 hasConcept C95444343 @default.
- W2945493658 hasConceptScore W2945493658C12554922 @default.
- W2945493658 hasConceptScore W2945493658C178790620 @default.
- W2945493658 hasConceptScore W2945493658C185592680 @default.
- W2945493658 hasConceptScore W2945493658C502942594 @default.
- W2945493658 hasConceptScore W2945493658C55904794 @default.
- W2945493658 hasConceptScore W2945493658C86803240 @default.
- W2945493658 hasConceptScore W2945493658C95444343 @default.
- W2945493658 hasIssue "2" @default.
- W2945493658 hasLocation W29454936581 @default.
- W2945493658 hasLocation W29454936582 @default.
- W2945493658 hasOpenAccess W2945493658 @default.
- W2945493658 hasPrimaryLocation W29454936581 @default.
- W2945493658 hasRelatedWork W1981292136 @default.
- W2945493658 hasRelatedWork W1987234305 @default.
- W2945493658 hasRelatedWork W2020993114 @default.
- W2945493658 hasRelatedWork W2021099451 @default.
- W2945493658 hasRelatedWork W2312579622 @default.
- W2945493658 hasRelatedWork W2322840078 @default.
- W2945493658 hasRelatedWork W2408045751 @default.
- W2945493658 hasRelatedWork W2886855338 @default.
- W2945493658 hasRelatedWork W2952064349 @default.
- W2945493658 hasRelatedWork W4232552561 @default.
- W2945493658 isParatext "false" @default.
- W2945493658 isRetracted "false" @default.
- W2945493658 magId "2945493658" @default.
- W2945493658 workType "article" @default.