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- W2945504219 endingPage "267" @default.
- W2945504219 startingPage "248" @default.
- W2945504219 abstract "Phytochemicals gained considerable interest during the past years as source to develop new treatment options for chemoprevention and cancer therapy. Motivated by the fact that a majority of established anticancer drugs are derived in one way or another from natural resources, we focused on shikonin, a naphthoquinone with high potentials to be further developed as preventive or therapeutic drug to fight cancer. Shikonin is the major chemical component of Lithospermum erythrorhizon (Purple Cromwell) roots. Traditionally, the root extract has been applied to cure dermatitis, burns, and wounds. Over the past three decades, the anti-inflammatory and anticancer effects of root extracts, isolated shikonin as well as semi-synthetic and synthetic derivatives and nanoformulations have been described. In vitro and in vivo experiments were conducted to understand the effect of shikonin at cellular and molecular levels. Preliminary clinical trials indicate the potential of shikonin for translation into clinical oncology. Shikonin exerts additive and synergistic interactions in combination with established chemotherapeutics, immunotherapeutic approaches, radiotherapy and other treatment modalities, which further underscores the potential of this phytochemical to be integrated into standard treatment regimens." @default.
- W2945504219 created "2019-05-29" @default.
- W2945504219 creator A5018815677 @default.
- W2945504219 creator A5022060346 @default.
- W2945504219 creator A5059565697 @default.
- W2945504219 date "2019-09-01" @default.
- W2945504219 modified "2023-10-12" @default.
- W2945504219 title "Shikonin derivatives for cancer prevention and therapy" @default.
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