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• W2945504815 endingPage "2028" @default.
• W2945504815 startingPage "2017" @default.
• W2945504815 abstract "In a search for safer and potent antitubercular agents, here a library of newly substituted dioxoisoindolinylmethyl-triazolyl-N-phenylacetamide derivatives (5a–l) has been synthesized via click chemistry approach. All synthesized compounds were evaluated for their antitubercular activity against Mycobacterium tuberculosis H37Rv (MTB). Among the screened compounds, 5d, 5e, 5h, and 5l showed good antitubercular activity. The compounds 5d and 5l have shown very effective antitubercular activity against Mycobacterium tuberculosis H37Rv (MTB) with MIC 12.5 μg/mL. All the newly synthesized compounds were thoroughly characterized by 1H NMR, 13C NMR, and HRMS spectral data. We further performed exploratory docking studies on the crystal structure of Mycobacterium tuberculosis enoyl reductase to demonstrate the mechanism of antitubercular activity." @default.
• W2945504815 created "2019-05-29" @default.
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• W2945504815 date "2019-05-16" @default.
• W2945504815 modified "2023-10-12" @default.
• W2945504815 title "Synthesis, antitubercular evaluation and molecular docking studies of phthalimide bearing 1,2,3-triazoles" @default.
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• W2945504815 doi "https://doi.org/10.1080/00397911.2019.1614630" @default.
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