Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945521636> ?p ?o ?g. }
- W2945521636 endingPage "692" @default.
- W2945521636 startingPage "675" @default.
- W2945521636 abstract "Abstract Multiple Sclerosis is an autoimmune disorder causing neurodegeneration mostly in young adults. Thereby, myelin is lost in the inflammatory lesions leaving unmyelinated axons at a high risk to degenerate. Oligodendrocyte precursor cells maintain their regenerative capacity into adulthood and are able to remyelinate axons if they are properly activated and differentiate. Neuronal activity influences the success of myelination indicating a close interplay between neurons and oligodendroglia. The myelination profile determines the distribution of voltage‐gated ion channels along the axon. Here, we analyze the distribution of the sodium channel subunit Nav1.6 and the ultrastructure of axons after cuprizone‐induced demyelination in transgenic mice expressing GFP in oligodendroglial cells. Using this mouse model, we found an increased number of GFP‐expressing oligodendroglial cells compared to untreated mice. Analyzing the axons, we found an increase in the number of nodes of Ranvier in mice that had received cuprizone. Furthermore, we found an enhanced portion of unmyelinated axons showing vesicles in the cytoplasm. These vesicles were labeled with VGlut1, indicating that they are involved in axonal signaling. Our results highlight the flexibility of axons towards changes in the glial compartment and depict the structural changes they undergo upon myelin removal. These findings might be considered if searching for new neuroprotective therapies that aim at blocking neuronal activity in order to avoid interfering with the process of remyelination." @default.
- W2945521636 created "2019-05-29" @default.
- W2945521636 creator A5037227734 @default.
- W2945521636 creator A5063505567 @default.
- W2945521636 creator A5079918208 @default.
- W2945521636 date "2019-07-02" @default.
- W2945521636 modified "2023-09-28" @default.
- W2945521636 title "Structural adaption of axons during de‐ and remyelination in the Cuprizone mouse model" @default.
- W2945521636 cites W1446040360 @default.
- W2945521636 cites W1532949410 @default.
- W2945521636 cites W1842838667 @default.
- W2945521636 cites W1847588449 @default.
- W2945521636 cites W1908391790 @default.
- W2945521636 cites W1921871464 @default.
- W2945521636 cites W1937650001 @default.
- W2945521636 cites W1971006243 @default.
- W2945521636 cites W1971355501 @default.
- W2945521636 cites W1972045793 @default.
- W2945521636 cites W1979316328 @default.
- W2945521636 cites W1979552960 @default.
- W2945521636 cites W1986436947 @default.
- W2945521636 cites W1986586470 @default.
- W2945521636 cites W1995291424 @default.
- W2945521636 cites W1995731471 @default.
- W2945521636 cites W1997220636 @default.
- W2945521636 cites W2000997085 @default.
- W2945521636 cites W2001188679 @default.
- W2945521636 cites W2005578607 @default.
- W2945521636 cites W2006312185 @default.
- W2945521636 cites W2006897862 @default.
- W2945521636 cites W2019746827 @default.
- W2945521636 cites W2020315449 @default.
- W2945521636 cites W2023693164 @default.
- W2945521636 cites W2028081619 @default.
- W2945521636 cites W2028803857 @default.
- W2945521636 cites W2045341846 @default.
- W2945521636 cites W2048082433 @default.
- W2945521636 cites W2049212652 @default.
- W2945521636 cites W2050596253 @default.
- W2945521636 cites W2055241344 @default.
- W2945521636 cites W2058785790 @default.
- W2945521636 cites W2059612947 @default.
- W2945521636 cites W2061068109 @default.
- W2945521636 cites W2061522969 @default.
- W2945521636 cites W2063015210 @default.
- W2945521636 cites W2065770359 @default.
- W2945521636 cites W2069955915 @default.
- W2945521636 cites W2076149037 @default.
- W2945521636 cites W2079735011 @default.
- W2945521636 cites W2090519295 @default.
- W2945521636 cites W2090546414 @default.
- W2945521636 cites W2100830657 @default.
- W2945521636 cites W2100904149 @default.
- W2945521636 cites W2103279601 @default.
- W2945521636 cites W2104010513 @default.
- W2945521636 cites W2115628640 @default.
- W2945521636 cites W2127779378 @default.
- W2945521636 cites W2128922463 @default.
- W2945521636 cites W2136912880 @default.
- W2945521636 cites W2140017053 @default.
- W2945521636 cites W2147554232 @default.
- W2945521636 cites W2152131288 @default.
- W2945521636 cites W2156549416 @default.
- W2945521636 cites W2168078141 @default.
- W2945521636 cites W2169924875 @default.
- W2945521636 cites W2180449937 @default.
- W2945521636 cites W2209818202 @default.
- W2945521636 cites W2223827011 @default.
- W2945521636 cites W2272917511 @default.
- W2945521636 cites W2295622075 @default.
- W2945521636 cites W2508176192 @default.
- W2945521636 cites W2524379288 @default.
- W2945521636 cites W2554475177 @default.
- W2945521636 cites W2589654173 @default.
- W2945521636 cites W2590681282 @default.
- W2945521636 cites W2616963432 @default.
- W2945521636 cites W2749489383 @default.
- W2945521636 cites W2758766872 @default.
- W2945521636 cites W2784326790 @default.
- W2945521636 cites W2793993113 @default.
- W2945521636 cites W2803141066 @default.
- W2945521636 cites W2811485141 @default.
- W2945521636 cites W91126227 @default.
- W2945521636 doi "https://doi.org/10.1111/bpa.12748" @default.
- W2945521636 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8028656" @default.
- W2945521636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31106489" @default.
- W2945521636 hasPublicationYear "2019" @default.
- W2945521636 type Work @default.
- W2945521636 sameAs 2945521636 @default.
- W2945521636 citedByCount "10" @default.
- W2945521636 countsByYear W29455216362020 @default.
- W2945521636 countsByYear W29455216362021 @default.
- W2945521636 countsByYear W29455216362022 @default.
- W2945521636 countsByYear W29455216362023 @default.
- W2945521636 crossrefType "journal-article" @default.
- W2945521636 hasAuthorship W2945521636A5037227734 @default.
- W2945521636 hasAuthorship W2945521636A5063505567 @default.
- W2945521636 hasAuthorship W2945521636A5079918208 @default.