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• W2945528018 abstract "The construction of complex gene-regulatory networks requires both inhibitory and upregulatory modules. However, the vast majority of RNA-based regulatory parts are inhibitory. Using a synthetic biology approach combined with SHAPE-seq, we explored the regulatory effect of RNA-binding protein (RBP)-RNA interactions in bacterial 5' UTRs. By positioning a library of RNA hairpins upstream of a reporter gene and co-expressing them with the matching RBP, we observed a set of regulatory responses, including translational stimulation, translational repression, and cooperative behavior. Our combined approach revealed three distinct states in vivo: in the absence of RBPs, the RNA molecules can be found in either a molten state that is amenable to translation or a structured phase that inhibits translation. In the presence of RBPs, the RNA molecules are in a semi-structured phase with partial translational capacity. Our work provides new insight into RBP-based regulation and a blueprint for designing complete gene-regulatory circuits at the post-transcriptional level." @default.
• W2945528018 created "2019-05-29" @default.
• W2945528018 creator A5002511176 @default.
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• W2945528018 date "2019-07-01" @default.
• W2945528018 modified "2023-10-13" @default.
• W2945528018 title "Synthetic 5′ UTRs Can Either Up- or Downregulate Expression upon RNA-Binding Protein Binding" @default.
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• W2945528018 doi "https://doi.org/10.1016/j.cels.2019.04.007" @default.
• W2945528018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31129060" @default.
• W2945528018 hasPublicationYear "2019" @default.
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