FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945541441> ?p ?o ?g. }

• W2945541441 abstract "Abstract Cryptococcosis is a major opportunistic infection and is one of the leading causes of death in adults living with HIV in sub-Saharan Africa. Recent estimates indicate that more than 130,000 people may die annually of cryptococcal meningitis in this region. Although complete diagnostic autopsy (CDA) is considered the gold standard for determining the cause of death, it is seldom performed in low income settings. In this study, a CDA was performed in 284 deceased patients from Mozambique (n = 223) and Brazil (n = 61). In depth histopathological and microbiological analyses were carried out in all cases dying of cryptococcosis. We determined the cryptococcal species, the molecular and sero-mating types and antifungal susceptibility. We also described the organs affected and reviewed the clinical presentation and patient management. Among the 284 cases included, 17 fatal cryptococcal infections were diagnosed. Cryptococcus was responsible for 16 deaths among the 163 HIV-positive patients (10%; 95%CI: 6–15%), including four maternal deaths. One third of the cases corresponded to C. gattii (VGI and VGIV molecular types, Bα and Cα strains) and the remaining infections typed were caused by C. neoformans var. Grubii (all VNI and Aα strains). The level of pre-mortem clinical suspicion was low (7/17, 41%), and 7/17 patients (41%) died within the first 72 hours of admission. Cryptococcosis was responsible for a significant proportion of AIDS-related mortality. The clinical diagnosis and patient management were inadequate, supporting the need for cryptococcal screening for early detection of the disease. This is the first report of the presence of C. gattii infection in Mozambique." @default.
• W2945541441 created "2019-05-29" @default.
• W2945541441 creator A5008818461 @default.
• W2945541441 creator A5013559838 @default.
• W2945541441 creator A5014460676 @default.
• W2945541441 creator A5015285519 @default.
• W2945541441 creator A5017235444 @default.
• W2945541441 creator A5024040223 @default.
• W2945541441 creator A5024161412 @default.
• W2945541441 creator A5030515780 @default.
• W2945541441 creator A5031903652 @default.
• W2945541441 creator A5041583388 @default.
• W2945541441 creator A5041749715 @default.
• W2945541441 creator A5042574065 @default.
• W2945541441 creator A5046990923 @default.
• W2945541441 creator A5053770608 @default.
• W2945541441 creator A5056091399 @default.
• W2945541441 creator A5056206913 @default.
• W2945541441 creator A5060792225 @default.
• W2945541441 creator A5062384694 @default.
• W2945541441 creator A5079326994 @default.
• W2945541441 creator A5081252952 @default.
• W2945541441 creator A5081603649 @default.
• W2945541441 creator A5086821007 @default.
• W2945541441 creator A5087508238 @default.
• W2945541441 creator A5089617808 @default.
• W2945541441 creator A5090083463 @default.
• W2945541441 creator A5090422579 @default.
• W2945541441 creator A5091742721 @default.
• W2945541441 date "2019-05-16" @default.
• W2945541441 modified "2023-10-17" @default.
• W2945541441 title "Mortality due to Cryptococcus neoformans and Cryptococcus gattii in low-income settings: an autopsy study" @default.
• W2945541441 cites W1839130247 @default.
• W2945541441 cites W1937733220 @default.
• W2945541441 cites W1969451874 @default.
• W2945541441 cites W1990709071 @default.
• W2945541441 cites W2001701680 @default.
• W2945541441 cites W2002815032 @default.
• W2945541441 cites W2004179192 @default.
• W2945541441 cites W2017665211 @default.
• W2945541441 cites W2021636821 @default.
• W2945541441 cites W2025476157 @default.
• W2945541441 cites W2026004843 @default.
• W2945541441 cites W2057651961 @default.
• W2945541441 cites W2065557130 @default.
• W2945541441 cites W2073363331 @default.
• W2945541441 cites W2079513681 @default.
• W2945541441 cites W2101195119 @default.
• W2945541441 cites W2104531436 @default.
• W2945541441 cites W2105745780 @default.
• W2945541441 cites W2118165589 @default.
• W2945541441 cites W2121969999 @default.
• W2945541441 cites W2126183097 @default.
• W2945541441 cites W2127250507 @default.
• W2945541441 cites W2150241610 @default.
• W2945541441 cites W2155068496 @default.
• W2945541441 cites W2156311275 @default.
• W2945541441 cites W2168233410 @default.
• W2945541441 cites W2172207388 @default.
• W2945541441 cites W2172864837 @default.
• W2945541441 cites W2192995462 @default.
• W2945541441 cites W2219027175 @default.
• W2945541441 cites W2294119443 @default.
• W2945541441 cites W2478438099 @default.
• W2945541441 cites W2497444145 @default.
• W2945541441 cites W2500734822 @default.
• W2945541441 cites W2550929752 @default.
• W2945541441 cites W2611697423 @default.
• W2945541441 cites W2765081524 @default.
• W2945541441 cites W4214908272 @default.
• W2945541441 cites W4238021038 @default.
• W2945541441 cites W925979150 @default.
• W2945541441 doi "https://doi.org/10.1038/s41598-019-43941-w" @default.
• W2945541441 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6522501" @default.
• W2945541441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31097746" @default.
• W2945541441 hasPublicationYear "2019" @default.
• W2945541441 type Work @default.
• W2945541441 sameAs 2945541441 @default.
• W2945541441 citedByCount "40" @default.
• W2945541441 countsByYear W29455414412019 @default.
• W2945541441 countsByYear W29455414412020 @default.
• W2945541441 countsByYear W29455414412021 @default.
• W2945541441 countsByYear W29455414412022 @default.
• W2945541441 countsByYear W29455414412023 @default.
• W2945541441 crossrefType "journal-article" @default.
• W2945541441 hasAuthorship W2945541441A5008818461 @default.
• W2945541441 hasAuthorship W2945541441A5013559838 @default.
• W2945541441 hasAuthorship W2945541441A5014460676 @default.
• W2945541441 hasAuthorship W2945541441A5015285519 @default.
• W2945541441 hasAuthorship W2945541441A5017235444 @default.
• W2945541441 hasAuthorship W2945541441A5024040223 @default.
• W2945541441 hasAuthorship W2945541441A5024161412 @default.
• W2945541441 hasAuthorship W2945541441A5030515780 @default.
• W2945541441 hasAuthorship W2945541441A5031903652 @default.
• W2945541441 hasAuthorship W2945541441A5041583388 @default.
• W2945541441 hasAuthorship W2945541441A5041749715 @default.
• W2945541441 hasAuthorship W2945541441A5042574065 @default.
• W2945541441 hasAuthorship W2945541441A5046990923 @default.
• W2945541441 hasAuthorship W2945541441A5053770608 @default.
• W2945541441 hasAuthorship W2945541441A5056091399 @default.

• next