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- W2945543637 endingPage "301" @default.
- W2945543637 startingPage "294" @default.
- W2945543637 abstract "Purpose of review Nonimmediate drug hypersensitivity reactions (NI-DHR) constitute the most complex group of drug allergy, with many drugs involved. Both parent drugs and their reactive metabolites can be implicated. Although with some drugs the number of metabolites is limited, with others it is quite extensive and many still remain to be identified. The diagnostic approaches are insufficient for the diagnosis and realistic approaches that reproduce the pathological response are lacking. Recent findings A wider view has now been considered, with the inclusion of several mechanisms that may contribute to drug hypersensitivity reactions (DHR): the classical hapten hypothesis, the danger signal and the pharmacological interaction. Monitoring the acute response provides relevant information about the mechanisms involved, with the identification of a large number of genes that can be over-expressed or under-expressed in the acute phase of the response. Assessment of risk of developing reactions can be verified by HLA associations. Summary Further knowledge of these NI-DHR, including molecular genetics and transcriptomic analysis, has enabled a better understanding and management of these reactions." @default.
- W2945543637 created "2019-05-29" @default.
- W2945543637 creator A5002569600 @default.
- W2945543637 creator A5010246711 @default.
- W2945543637 creator A5012775442 @default.
- W2945543637 creator A5017356920 @default.
- W2945543637 creator A5020968041 @default.
- W2945543637 date "2019-08-01" @default.
- W2945543637 modified "2023-10-16" @default.
- W2945543637 title "Role of T cells in non-immediate drug allergy reactions" @default.
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