Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945548092> ?p ?o ?g. }
- W2945548092 endingPage "98" @default.
- W2945548092 startingPage "73" @default.
- W2945548092 abstract "N-methyl-D-aspartate receptors (NMDARs) are a family of ionotropic glutamate receptors mainly known to mediate excitatory synaptic transmission and plasticity. Interestingly, low-dose NMDAR antagonists lead to increased, instead of decreased, functional connectivity; and they could cause schizophrenia- and/or antidepressant-like behavior in both humans and rodents. In addition, human genetic evidences indicate that NMDAR loss of function mutations underlie certain forms of epilepsy, a disease featured with abnormal brain hyperactivity. Together, they all suggest that under certain conditions, NMDAR activation actually lead to inhibition, but not excitation, of the global neuronal network. Apparently, these phenomena are rather counterintuitive to the receptor's basic role in mediating excitatory synaptic transmission. How could it happen? Recently, this has become a crucial question in order to fully understand the complexity of NMDAR function, particularly in disease. Over the past decades, different theories have been proposed to address this question. These include theories of “NMDARs on inhibitory neurons are more sensitive to antagonism”, or “basal NMDAR activity actually inhibits excitatory synapse”, etc. Our review summarizes these efforts, and also provides an introduction of NMDARs, inhibitory neurons, and their relationships with the related diseases. Advances in the development of novel NMDAR pharmacological tools, particularly positive allosteric modulators, are also included to provide insights into potential intervention strategies." @default.
- W2945548092 created "2019-05-29" @default.
- W2945548092 creator A5005895138 @default.
- W2945548092 creator A5035939534 @default.
- W2945548092 creator A5050789105 @default.
- W2945548092 creator A5053688778 @default.
- W2945548092 creator A5061353154 @default.
- W2945548092 date "2018-12-01" @default.
- W2945548092 modified "2023-09-30" @default.
- W2945548092 title "How could N-Methyl-D-Aspartate Receptor Antagonists Lead to Excitation Instead of Inhibition?" @default.
- W2945548092 cites W119236702 @default.
- W2945548092 cites W133907179 @default.
- W2945548092 cites W1505424611 @default.
- W2945548092 cites W1535045684 @default.
- W2945548092 cites W15515072 @default.
- W2945548092 cites W1577989916 @default.
- W2945548092 cites W1602293986 @default.
- W2945548092 cites W1606946990 @default.
- W2945548092 cites W1799512027 @default.
- W2945548092 cites W1833075442 @default.
- W2945548092 cites W1862839122 @default.
- W2945548092 cites W1909841186 @default.
- W2945548092 cites W1914381346 @default.
- W2945548092 cites W1918304474 @default.
- W2945548092 cites W1963718884 @default.
- W2945548092 cites W1964353540 @default.
- W2945548092 cites W1965970535 @default.
- W2945548092 cites W1968700646 @default.
- W2945548092 cites W1968956259 @default.
- W2945548092 cites W1970377013 @default.
- W2945548092 cites W1970448316 @default.
- W2945548092 cites W1970897832 @default.
- W2945548092 cites W1971305731 @default.
- W2945548092 cites W1973042782 @default.
- W2945548092 cites W1975522748 @default.
- W2945548092 cites W1975626677 @default.
- W2945548092 cites W1976289522 @default.
- W2945548092 cites W1976392245 @default.
- W2945548092 cites W1977048478 @default.
- W2945548092 cites W1977998932 @default.
- W2945548092 cites W1978930750 @default.
- W2945548092 cites W1979844761 @default.
- W2945548092 cites W1981097208 @default.
- W2945548092 cites W1983092434 @default.
- W2945548092 cites W1987520241 @default.
- W2945548092 cites W1988244113 @default.
- W2945548092 cites W1989781329 @default.
- W2945548092 cites W1990650378 @default.
- W2945548092 cites W1990653946 @default.
- W2945548092 cites W1992910467 @default.
- W2945548092 cites W1994084016 @default.
- W2945548092 cites W1994664270 @default.
- W2945548092 cites W1995031373 @default.
- W2945548092 cites W1995742542 @default.
- W2945548092 cites W1997010275 @default.
- W2945548092 cites W1997141836 @default.
- W2945548092 cites W1997298055 @default.
- W2945548092 cites W1998952799 @default.
- W2945548092 cites W2001555806 @default.
- W2945548092 cites W2001744744 @default.
- W2945548092 cites W2001954021 @default.
- W2945548092 cites W2002896974 @default.
- W2945548092 cites W2006955019 @default.
- W2945548092 cites W2007034511 @default.
- W2945548092 cites W2008020964 @default.
- W2945548092 cites W2008639041 @default.
- W2945548092 cites W2009560845 @default.
- W2945548092 cites W2009971242 @default.
- W2945548092 cites W2011515475 @default.
- W2945548092 cites W2012636735 @default.
- W2945548092 cites W2013514700 @default.
- W2945548092 cites W2015701831 @default.
- W2945548092 cites W2016417450 @default.
- W2945548092 cites W2016712906 @default.
- W2945548092 cites W2022470748 @default.
- W2945548092 cites W2023081218 @default.
- W2945548092 cites W2023235195 @default.
- W2945548092 cites W2023979631 @default.
- W2945548092 cites W2024380057 @default.
- W2945548092 cites W2024702779 @default.
- W2945548092 cites W2024770631 @default.
- W2945548092 cites W2024896807 @default.
- W2945548092 cites W2025179692 @default.
- W2945548092 cites W2026643535 @default.
- W2945548092 cites W2028372287 @default.
- W2945548092 cites W2028594041 @default.
- W2945548092 cites W2028867053 @default.
- W2945548092 cites W2028884770 @default.
- W2945548092 cites W2029925498 @default.
- W2945548092 cites W2031150114 @default.
- W2945548092 cites W2031779883 @default.
- W2945548092 cites W2032216760 @default.
- W2945548092 cites W2032791726 @default.
- W2945548092 cites W2034651412 @default.
- W2945548092 cites W2034965090 @default.
- W2945548092 cites W2036796078 @default.
- W2945548092 cites W2037121399 @default.
- W2945548092 cites W2037549116 @default.