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• W2945552786 abstract "Abstract Early detection of colorectal cancer and monitoring the progress in colon carcinogenesis stages is essential to reduce mortality. Therefore, there is continuous search for noninvasive biomarkers with high stability and good sensitivity and specificity. miRNAs have attracted attention as promising biomarkers as they are stably expressed in circulation. The aim of our study is to evaluate the aberrant expression of circulating miRNAs during the stepwise progress of colitis‐associated colon cancer. This was accomplished through assessing the expression levels of five miRNAs (miR‐141, miR‐15b, miR‐17‐3p, miR‐21, and miR‐29a) in serum and their corresponding tissue samples through the different cycles of colorectal carcinogenesis cascade using the azoxymethane/dextran sulfate sodium murine model. We also compared the diagnostic performance of these selected miRNAs with the conventional tumor biomarkers CEA and CA 19‐9. The results of our study revealed that the expression levels of those miRNAs were dynamically changing in accordance with the tumor development state. Moreover, their aberrant expression in serum was statistically correlated with that in tissue. Our data also revealed that serum miR‐15b, miR‐21, and miR‐29a showed the best performance in terms of diagnostic power. Our findings highlight the efficiency of these circulating miRNAs not only for early diagnostics purposes, but also for monitoring progress in the colorectal carcinogenesis process, and therefore encouraging integrating these noninvasive biomarkers into the clinical diagnostic settings beside the traditional diagnostic markers for accurate screening of the early progress of colon carcinogenesis." @default.
• W2945552786 created "2019-05-29" @default.
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• W2945552786 date "2019-05-16" @default.
• W2945552786 modified "2023-10-18" @default.
• W2945552786 title "The diagnostic efficacy of circulating miRNAs in monitoring the early development of colitis‐induced colorectal cancer" @default.
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• W2945552786 doi "https://doi.org/10.1002/jcb.28925" @default.
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