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- W2945555961 endingPage "20181031" @default.
- W2945555961 startingPage "20181031" @default.
- W2945555961 abstract "Clinical trials are powerful weapons in the battle against nasopharyngeal carcinoma (NPC). Based on clinical trials conducted in the past two decades, concurrent chemoradiotherapy combined with adjuvant chemotherapy or induction chemotherapy has been recommended as the standard treatment for locoregionally advanced NPC in various guidelines. However, there remain shortcomings concerning current treatment modalities that should be refined in future research. In this article, we review the achievements of published clinical trials for locoregionally advanced NPC and propose future directions for subsequent clinical trials. We believe that refinement of current regimens of chemotherapy, de-intensification of treatment for specific groups of patients, developing personalized treatment based on predictors ( e.g. applying plasma Epstein-Barr virus DNA) and investigating novel therapies, such as targeted therapy and immunotherapy, should be applied with the highest priority when designing clinical trials for locoregionally advanced NPC in the next decade." @default.
- W2945555961 created "2019-05-29" @default.
- W2945555961 creator A5016684571 @default.
- W2945555961 creator A5026530982 @default.
- W2945555961 creator A5054603016 @default.
- W2945555961 creator A5090632616 @default.
- W2945555961 date "2019-10-01" @default.
- W2945555961 modified "2023-10-13" @default.
- W2945555961 title "The next decade of clinical trials in locoregionally advanced nasopharyngeal carcinoma" @default.
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- W2945555961 doi "https://doi.org/10.1259/bjr.20181031" @default.
- W2945555961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6774586" @default.
- W2945555961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31112398" @default.
- W2945555961 hasPublicationYear "2019" @default.
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