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• W2945559086 startingPage "2457" @default.
• W2945559086 abstract "Our previous findings indicate that A2A and D2 receptors are co-expressed on adult rat striatal astrocytes and on the astrocyte processes, and that A2A-D2 receptor–receptor interaction can control the release of glutamate from the processes. Functional evidence suggests that the receptor–receptor interaction was based on heteromerization of native A2A and D2 receptors at the plasma membrane of striatal astrocyte processes. We here provide biochemical and biophysical evidence confirming that receptor–receptor interaction between A2A and D2 receptors at the astrocyte plasma membrane is based on A2A-D2 heteromerization. To our knowledge, this is the first direct demonstration of the ability of native A2A and D2 receptors to heteromerize on glial cells. As striatal astrocytes are recognized to be involved in Parkinson’s pathophysiology, the findings that adenosine A2A and dopamine D2 receptors can form A2A-D2 heteromers on the astrocytes in the striatum (and that these heteromers can play roles in the control of the striatal glutamatergic transmission) may shed light on the molecular mechanisms involved in the pathogenesis of the disease." @default.
• W2945559086 created "2019-05-29" @default.
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• W2945559086 date "2019-05-17" @default.
• W2945559086 modified "2023-10-12" @default.
• W2945559086 title "A2A-D2 Heteromers on Striatal Astrocytes: Biochemical and Biophysical Evidence" @default.
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• W2945559086 doi "https://doi.org/10.3390/ijms20102457" @default.
• W2945559086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6566402" @default.
• W2945559086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31109007" @default.
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