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• W2945559571 abstract "Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disorder presenting with spastic paraparesis, sphincter dysfunction, and mild sensory disturbance in the lower extremities, which develops in a small minority of HTLV-1-infected individuals. HTLV-1-specific T cells are efficiently activated through dedicated human leukocyte antigen-mediated mechanisms, a process considered deeply involved with its pathogenesis. It has been reported that the lifetime risk of developing HAM/TSP differs between ethnic groups, and there is an association between HTLV-1 tax gene subgroups (i.e., tax subgroup-A or -B), which correspond to HTLV-1 “cosmopolitan subtype 1a subgroup A (i.e., transcontinental subgroup)” and “cosmopolitan subtype 1a subgroup B (i.e., Japanese subgroup)”, respectively, and the risk of HAM/TSP in the Japanese population. These findings suggest that a given host’s susceptibility to HAM/TSP is deeply connected with both differences in genetically determined components of the host immune response and HTLV-1 subgroup. Therefore, it is crucial for ongoing work to focus on developing novel treatments and preventative approaches for HAM/TSP. In this review, based on an overview of the topic and our latest research findings, the role of the HTLV-1 subgroup on the effects of virus–host interactions in the pathogenesis of HAM/TSP is discussed." @default.
• W2945559571 created "2019-05-29" @default.
• W2945559571 creator A5082864942 @default.
• W2945559571 date "2019-05-15" @default.
• W2945559571 modified "2023-10-14" @default.
• W2945559571 title "Association Between HTLV-1 Genotypes and Risk of HAM/TSP" @default.
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• W2945559571 doi "https://doi.org/10.3389/fmicb.2019.01101" @default.
• W2945559571 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6529560" @default.
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