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- W2945561337 abstract "Chronic peripheral elevation of interleukin 6 (IL-6) in humans is associated with cognitive deficits. 4- and 24-month-old IL-6-deficient C57BL/6J (IL-6KO) and reference wild-type (WT) mice were tested in an object recognition test. Discrimination ratios and recognition indexes were significantly lower in 4-month-old IL-6KO and in 24-month-old WT mice vs 4-month-old WT animals. Their discrimination ratios had negative values and recognition indexes were below 50% indicating inability to differentiate the novel from the familiar object after 1-hour delay. In 24-month-old IL-6KO mice recognition index reached 53.17% indicating that their recognition memory was not worsened with age in comparison with younger IL-6-deficient animals. Results of holeboard and elevated plus maze indicated that this effect was memory specific. Inborn IL-6 deficiency attenuated recognition memory in 4-month-old mice and did not altered recognition memory in aged animals. IL-6 signalling may constitute a target for development of the protection against memory disturbances connected with IL-6 overexpression." @default.
- W2945561337 created "2019-05-29" @default.
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- W2945561337 date "2019-05-25" @default.
- W2945561337 modified "2023-09-23" @default.
- W2945561337 title "Significance of IL-6 Deficiency in Recognition Memory in Young Adult and Aged Mice" @default.
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- W2945561337 doi "https://doi.org/10.1007/s10519-019-09959-6" @default.
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