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• W2945563485 abstract "The metabolism of lactate is important for infant gut health and may lead to acute lactate and/or H 2 accumulation, pain, and crying as observed in colicky infants. Functional human studies often faced ethical challenges due to invasive medical procedures; thus, in this study, we implemented PolyFermS fermentation models to mimic the infant proximal colon, which were inoculated with immobilized fecal microbiota of two 2-month-old infants. We investigated the impact of pH, retention time, and accumulation of dl -lactate on microbiota composition and metabolic activity. We found that a drop in pH from 6.0 to 5.0 led to increased LPB and decreased LUB concomitantly with lactate accumulation. Increasing the RT resulted in complete lactate consumption associated with increased LUB. Our data highlight for the first time the impact of key abiotic factors on the metabolism of lactate, which is an important intermediate product for ecology and infant health." @default.
• W2945563485 created "2019-05-29" @default.
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• W2945563485 date "2019-08-27" @default.
• W2945563485 modified "2023-10-16" @default.
• W2945563485 title "Lactate Metabolism Is Strongly Modulated by Fecal Inoculum, pH, and Retention Time in PolyFermS Continuous Colonic Fermentation Models Mimicking Young Infant Proximal Colon" @default.
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• W2945563485 doi "https://doi.org/10.1128/msystems.00264-18" @default.
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