FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945575042> ?p ?o ?g. }

• W2945575042 endingPage "266" @default.
• W2945575042 startingPage "259" @default.
• W2945575042 abstract "Background Around 30% of individuals with schizophrenia remain symptomatic and significantly impaired despite antipsychotic treatment and are considered to be treatment resistant. Clinicians are currently unable to predict which patients are at higher risk of treatment resistance. Aims To determine whether genetic liability for schizophrenia and/or clinical characteristics measurable at illness onset can prospectively indicate a higher risk of treatment-resistant psychosis (TRP). Method In 1070 individuals with schizophrenia or related psychotic disorders, schizophrenia polygenic risk scores (PRS) and large copy number variations (CNVs) were assessed for enrichment in TRP. Regression and machine-learning approaches were used to investigate the association of phenotypes related to demographics, family history, premorbid factors and illness onset with TRP. Results Younger age at onset (odds ratio 0.94, P = 7.79 × 10 −13 ) and poor premorbid social adjustment (odds ratio 1.64, P = 2.41 × 10 −4 ) increased risk of TRP in univariate regression analyses. These factors remained associated in multivariate regression analyses, which also found lower premorbid IQ (odds ratio 0.98, P = 7.76 × 10 −3 ), younger father's age at birth (odds ratio 0.97, P = 0.015) and cannabis use (odds ratio 1.60, P = 0.025) increased the risk of TRP. Machine-learning approaches found age at onset to be the most important predictor and also identified premorbid IQ and poor social adjustment as predictors of TRP, mirroring findings from regression analyses. Genetic liability for schizophrenia was not associated with TRP. Conclusions People with an earlier age at onset of psychosis and poor premorbid functioning are more likely to be treatment resistant. The genetic architecture of susceptibility to schizophrenia may be distinct from that of treatment outcomes." @default.
• W2945575042 created "2019-05-29" @default.
• W2945575042 creator A5018396739 @default.
• W2945575042 creator A5019789097 @default.
• W2945575042 creator A5026352442 @default.
• W2945575042 creator A5032995667 @default.
• W2945575042 creator A5036033229 @default.
• W2945575042 creator A5045921453 @default.
• W2945575042 creator A5051744112 @default.
• W2945575042 creator A5054983889 @default.
• W2945575042 creator A5057411505 @default.
• W2945575042 creator A5061702670 @default.
• W2945575042 date "2019-06-03" @default.
• W2945575042 modified "2023-09-28" @default.
• W2945575042 title "Clinical indicators of treatment-resistant psychosis" @default.
• W2945575042 cites W1565231669 @default.
• W2945575042 cites W1608887304 @default.
• W2945575042 cites W1831050183 @default.
• W2945575042 cites W1836636540 @default.
• W2945575042 cites W1964512314 @default.
• W2945575042 cites W1980410354 @default.
• W2945575042 cites W1982177100 @default.
• W2945575042 cites W1992436001 @default.
• W2945575042 cites W1994495351 @default.
• W2945575042 cites W1997338841 @default.
• W2945575042 cites W2020663825 @default.
• W2945575042 cites W2029856455 @default.
• W2945575042 cites W2036480935 @default.
• W2945575042 cites W2086619421 @default.
• W2945575042 cites W2086982565 @default.
• W2945575042 cites W2108968692 @default.
• W2945575042 cites W2126718294 @default.
• W2945575042 cites W2138231636 @default.
• W2945575042 cites W2152770536 @default.
• W2945575042 cites W2216458865 @default.
• W2945575042 cites W2278070452 @default.
• W2945575042 cites W2280484203 @default.
• W2945575042 cites W2510482597 @default.
• W2945575042 cites W2517254183 @default.
• W2945575042 cites W2578041951 @default.
• W2945575042 cites W2586701058 @default.
• W2945575042 cites W2737015692 @default.
• W2945575042 cites W2762783509 @default.
• W2945575042 cites W2777388159 @default.
• W2945575042 cites W2856714072 @default.
• W2945575042 cites W2888848724 @default.
• W2945575042 cites W2893799782 @default.
• W2945575042 cites W4246090800 @default.
• W2945575042 doi "https://doi.org/10.1192/bjp.2019.120" @default.
• W2945575042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31155017" @default.
• W2945575042 hasPublicationYear "2019" @default.
• W2945575042 type Work @default.
• W2945575042 sameAs 2945575042 @default.
• W2945575042 citedByCount "41" @default.
• W2945575042 countsByYear W29455750422020 @default.
• W2945575042 countsByYear W29455750422021 @default.
• W2945575042 countsByYear W29455750422022 @default.
• W2945575042 countsByYear W29455750422023 @default.
• W2945575042 crossrefType "journal-article" @default.
• W2945575042 hasAuthorship W2945575042A5018396739 @default.
• W2945575042 hasAuthorship W2945575042A5019789097 @default.
• W2945575042 hasAuthorship W2945575042A5026352442 @default.
• W2945575042 hasAuthorship W2945575042A5032995667 @default.
• W2945575042 hasAuthorship W2945575042A5036033229 @default.
• W2945575042 hasAuthorship W2945575042A5045921453 @default.
• W2945575042 hasAuthorship W2945575042A5051744112 @default.
• W2945575042 hasAuthorship W2945575042A5054983889 @default.
• W2945575042 hasAuthorship W2945575042A5057411505 @default.
• W2945575042 hasAuthorship W2945575042A5061702670 @default.
• W2945575042 hasBestOaLocation W29455750422 @default.
• W2945575042 hasConcept C118552586 @default.
• W2945575042 hasConcept C126322002 @default.
• W2945575042 hasConcept C156957248 @default.
• W2945575042 hasConcept C15744967 @default.
• W2945575042 hasConcept C2776412080 @default.
• W2945575042 hasConcept C2777767895 @default.
• W2945575042 hasConcept C2779134260 @default.
• W2945575042 hasConcept C2779727114 @default.
• W2945575042 hasConcept C71924100 @default.
• W2945575042 hasConceptScore W2945575042C118552586 @default.
• W2945575042 hasConceptScore W2945575042C126322002 @default.
• W2945575042 hasConceptScore W2945575042C156957248 @default.
• W2945575042 hasConceptScore W2945575042C15744967 @default.
• W2945575042 hasConceptScore W2945575042C2776412080 @default.
• W2945575042 hasConceptScore W2945575042C2777767895 @default.
• W2945575042 hasConceptScore W2945575042C2779134260 @default.
• W2945575042 hasConceptScore W2945575042C2779727114 @default.
• W2945575042 hasConceptScore W2945575042C71924100 @default.
• W2945575042 hasIssue "5" @default.
• W2945575042 hasLocation W29455750421 @default.
• W2945575042 hasLocation W29455750422 @default.
• W2945575042 hasOpenAccess W2945575042 @default.
• W2945575042 hasPrimaryLocation W29455750421 @default.
• W2945575042 hasRelatedWork W1976740474 @default.
• W2945575042 hasRelatedWork W2003919441 @default.
• W2945575042 hasRelatedWork W2124800977 @default.
• W2945575042 hasRelatedWork W2131273350 @default.
• W2945575042 hasRelatedWork W2135078674 @default.

• next