FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945578110> ?p ?o ?g. }

• W2945578110 endingPage "606" @default.
• W2945578110 startingPage "591" @default.
• W2945578110 abstract "In this paper, we discussed the similarities and differences in d6 low-spin half-sandwich ruthenium, rhodium and iridium complexes containing 2,2′-biimidazole (H2biim). Three new complexes, {[RuCl(H2biim)(η6-p-cymene)]PF6}2·H2O (1), [(η5-Cp)RhCl(H2biim)]PF6 (2), and [(η5-Cp)IrCl(H2biim)]PF6 (3), were fully characterized by CHN, X-ray diffraction analysis, UV–Vis, FTIR, and 1H, 13C and 15N NMR spectroscopies. The complexes exhibit a typical pseudooctahedral piano-stool geometry, in which the aromatic arene ring (p-cymene or Cp) forms the seat, while the bidentate 2,2′-biimidazole and chloride ion form the three legs of the piano stool. Moreover, the cytotoxic activities of the compounds were examined in the LoVo, HL-60, MV-4-11, MCF-7 human cancer cell lines and BALB/3T3 normal mouse fibroblasts. Notably, the investigated complexes showed no cytotoxic effects towards the normal BALB/3T3 cell line compared to cisplatin, which has an IC50 value of 2.20 µg. Importantly, 1 displayed the highest activity against HL-60 (IC50 4.35 µg). To predict a binding mode, we explored the potential interactions of the metal complexes with CT-DNA and protein using UV absorption and circular dichroism. The obtained data suggest that the complexes could interact with CT-DNA via an outside binding mode. Moreover, binding of the complexes with the GSH via UV–Vis and ESI mass spectra was determined. Comparative studies have shown that the rhodium complex (2) is the most GSH reactive, which is probably responsible for its deactivation towards LoVo and MCF-7 tumour cells. The influence of the metal ion on the biological activity of isostructural Rh(III) and Ir(III) complexes was an important goal of the presented investigation." @default.
• W2945578110 created "2019-05-29" @default.
• W2945578110 creator A5022446752 @default.
• W2945578110 creator A5035626988 @default.
• W2945578110 creator A5053931786 @default.
• W2945578110 creator A5060305246 @default.
• W2945578110 creator A5069006455 @default.
• W2945578110 creator A5086440017 @default.
• W2945578110 creator A5087532476 @default.
• W2945578110 date "2019-05-21" @default.
• W2945578110 modified "2023-10-03" @default.
• W2945578110 title "Similarities and differences in d6 low-spin ruthenium, rhodium and iridium half-sandwich complexes: synthesis, structure, cytotoxicity and interaction with biological targets" @default.
• W2945578110 cites W182991903 @default.
• W2945578110 cites W1964314803 @default.
• W2945578110 cites W1966817155 @default.
• W2945578110 cites W1967500752 @default.
• W2945578110 cites W1977935357 @default.
• W2945578110 cites W1983311859 @default.
• W2945578110 cites W1989831408 @default.
• W2945578110 cites W1990170643 @default.
• W2945578110 cites W1991651763 @default.
• W2945578110 cites W2000587059 @default.
• W2945578110 cites W2003575529 @default.
• W2945578110 cites W2004612743 @default.
• W2945578110 cites W2005723165 @default.
• W2945578110 cites W2006370393 @default.
• W2945578110 cites W2007290228 @default.
• W2945578110 cites W2008002124 @default.
• W2945578110 cites W2008831150 @default.
• W2945578110 cites W2013959470 @default.
• W2945578110 cites W2016504877 @default.
• W2945578110 cites W2019661323 @default.
• W2945578110 cites W2028364813 @default.
• W2945578110 cites W2048861701 @default.
• W2945578110 cites W2049599520 @default.
• W2945578110 cites W2053726603 @default.
• W2945578110 cites W2059205366 @default.
• W2945578110 cites W2061417686 @default.
• W2945578110 cites W2069602336 @default.
• W2945578110 cites W2074156770 @default.
• W2945578110 cites W2074220715 @default.
• W2945578110 cites W2086627300 @default.
• W2945578110 cites W2089599861 @default.
• W2945578110 cites W2099938318 @default.
• W2945578110 cites W2109689528 @default.
• W2945578110 cites W2126695283 @default.
• W2945578110 cites W2129213133 @default.
• W2945578110 cites W2131350133 @default.
• W2945578110 cites W2140928624 @default.
• W2945578110 cites W2142482905 @default.
• W2945578110 cites W2146215891 @default.
• W2945578110 cites W2150303730 @default.
• W2945578110 cites W2152244168 @default.
• W2945578110 cites W2155688568 @default.
• W2945578110 cites W2184512639 @default.
• W2945578110 cites W2253778084 @default.
• W2945578110 cites W2333726981 @default.
• W2945578110 cites W2531583030 @default.
• W2945578110 cites W2765201694 @default.
• W2945578110 cites W2802843233 @default.
• W2945578110 cites W2885264837 @default.
• W2945578110 cites W2888961266 @default.
• W2945578110 cites W3994596 @default.
• W2945578110 cites W4251747302 @default.
• W2945578110 cites W966381494 @default.
• W2945578110 doi "https://doi.org/10.1007/s00775-019-01665-2" @default.
• W2945578110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6598960" @default.
• W2945578110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31115765" @default.
• W2945578110 hasPublicationYear "2019" @default.
• W2945578110 type Work @default.
• W2945578110 sameAs 2945578110 @default.
• W2945578110 citedByCount "24" @default.
• W2945578110 countsByYear W29455781102019 @default.
• W2945578110 countsByYear W29455781102020 @default.
• W2945578110 countsByYear W29455781102021 @default.
• W2945578110 countsByYear W29455781102022 @default.
• W2945578110 countsByYear W29455781102023 @default.
• W2945578110 crossrefType "journal-article" @default.
• W2945578110 hasAuthorship W2945578110A5022446752 @default.
• W2945578110 hasAuthorship W2945578110A5035626988 @default.
• W2945578110 hasAuthorship W2945578110A5053931786 @default.
• W2945578110 hasAuthorship W2945578110A5060305246 @default.
• W2945578110 hasAuthorship W2945578110A5069006455 @default.
• W2945578110 hasAuthorship W2945578110A5086440017 @default.
• W2945578110 hasAuthorship W2945578110A5087532476 @default.
• W2945578110 hasBestOaLocation W29455781101 @default.
• W2945578110 hasConcept C121332964 @default.
• W2945578110 hasConcept C124668440 @default.
• W2945578110 hasConcept C133571119 @default.
• W2945578110 hasConcept C155647269 @default.
• W2945578110 hasConcept C161790260 @default.
• W2945578110 hasConcept C178516000 @default.
• W2945578110 hasConcept C178790620 @default.
• W2945578110 hasConcept C185592680 @default.
• W2945578110 hasConcept C20621625 @default.
• W2945578110 hasConcept C521398313 @default.
• W2945578110 hasConcept C52703039 @default.
• W2945578110 hasConcept C528581852 @default.

• next