Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945579188> ?p ?o ?g. }
- W2945579188 abstract "In modern medicine, physicians are frequently forced to balance immune suppression against immune stimulation to treat patients such as those undergoing transplants and chemotherapy. More-targeted therapies designed to preserve immunity and prevent opportunistic fungal infection in these patients could be informed by an understanding of how fungi interact with professional and nonprofessional immune cells in mucosal candidiasis. In this study, we intravitally imaged these host-pathogen dynamics during Candida infection in a transparent vertebrate model host, the zebrafish. Single-cell imaging revealed an unexpected partitioning of the inflammatory response between phagocytes and epithelial cells. Surprisingly, we found that in vivo cytokine profiles more closely match in vitro responses of epithelial cells rather than phagocytes. Furthermore, we identified a disconnect between canonical inflammatory cytokine production and phagocyte recruitment to the site of infection, implicating noncytokine chemoattractants. Our study contributes to a new appreciation for the specialization and cross talk among cell types during mucosal infection." @default.
- W2945579188 created "2019-05-29" @default.
- W2945579188 creator A5005992574 @default.
- W2945579188 creator A5006376956 @default.
- W2945579188 creator A5040615736 @default.
- W2945579188 creator A5063850392 @default.
- W2945579188 creator A5091199408 @default.
- W2945579188 date "2019-06-25" @default.
- W2945579188 modified "2023-10-14" @default.
- W2945579188 title "Intravital Imaging Reveals Divergent Cytokine and Cellular Immune Responses to Candida albicans and Candida parapsilosis" @default.
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