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- W2945582672 abstract "BackgroundOncology treatments have changed from chemotherapies to targeted therapies and more recently immuno-oncology. This has posed special challenges in the field of health technology assessment (HTA): capturing quality of life (QOL) associated with toxicity due to chemotherapy, crossover upon progression in targeted therapy trials, and survival extrapolation for immuno-oncology drugs.ObjectivesTo showcase 20 years of Value in Health (ViH) publications in oncology.MethodsA review was undertaken of oncology articles published in ViH from May 1998 to August 2018. Full-length articles published in ViH with the keywords “oncology,” “cancer,” “h(a)ematology,” and “malignancy” were included for review. Conference abstracts were excluded.ResultsFour major themes were identified: (1) QOL and the development of multiple functional assessment of cancer therapy tools and mapping instruments; (2) analysis of clinical evidence using indirect comparisons, network analyses, and adjustment for crossovers; (3) modeling, Markov models, partitioned survival models, and extrapolation methods; and (4) financial implications and how to deal with uncertainty, introduction of conditional reimbursement, managed entry, and risk share agreements.DiscussionThis review article highlights the important role ViH has played in disseminating HTA research in oncology. A few key issues loom on the horizon: precision medicine, further development and practical application of new QOL measures, methods for translating clinical evidence, and exploration of modeling techniques. For a better understanding of the complex interplay between access and financial risk management, ViH will no doubt continue to promote pioneering research in HTA and oncology." @default.
- W2945582672 created "2019-05-29" @default.
- W2945582672 creator A5082008789 @default.
- W2945582672 creator A5082663721 @default.
- W2945582672 creator A5090549280 @default.
- W2945582672 date "2019-05-01" @default.
- W2945582672 modified "2023-10-13" @default.
- W2945582672 title "Health Technology Assessment Challenges in Oncology: 20 Years of Value in Health" @default.
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- W2945582672 doi "https://doi.org/10.1016/j.jval.2019.01.001" @default.
- W2945582672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31104740" @default.
- W2945582672 hasPublicationYear "2019" @default.
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