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- W2945582761 abstract "Background Caffeine is commonly regarded as the treatment of choice for neonatal apnoea. However, limited data on the developmental pharmacokinetics and pharmacogenetics were available in Chinese premature infants. The objective of this study was to develop a population pharmacokinetic model of caffeine after intravenous administration to Chinese neonates with apnoea of prematurity (AOP) and evaluate the impact of developmental pharmacogenetics of CYP1A2. Methods Sparse pharmacokinetic samples were collected from AOP newborns receiving caffeine citrate at a loading dose of 20 mg/kg/d and maintenance dose of 5–10 mg/kg/d. Population pharmacokinetic-pharmacogenetic analysis of caffeine was performed using NONMEM. Eight CYP1A2 polymorphisms were genotyped. Results A total of 99 newborns with a mean (SD) postmenstrual age of 32.0 (2.16) (range 22.3 - 38.0) weeks were included in the present study. Pharmacokinetic data fitted an one-compartment model with first-order absorption and elimination. Current weight, postmenstrual age and serum creatinine concentration were significant covariates influencing caffeine clearance. None of tested CYP1A2 polymorphisms had significant impact on caffeine pharmacokinetics. Conclusion The population pharmacokinetics-pharmacogenetics of caffeine was evaluated in Chinese AOP premature infants. This developmental pharmacokinetic model can be helpful to individualize caffeine therapy. Disclosure(s) Nothing to disclose" @default.
- W2945582761 created "2019-05-29" @default.
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- W2945582761 date "2019-05-17" @default.
- W2945582761 modified "2023-09-26" @default.
- W2945582761 title "P71 Population pharmacokinetics and pharmacogenetics of caffeine in Chinese premature infants with apnoea of prematurity" @default.
- W2945582761 doi "https://doi.org/10.1136/archdischild-2019-esdppp.109" @default.
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