Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945583619> ?p ?o ?g. }
- W2945583619 endingPage "96" @default.
- W2945583619 startingPage "82" @default.
- W2945583619 abstract "The expression of Toll-like receptors (TLRs) on antigen presenting cells, especially dendritic cells, offers several sensitive mediators to trigger an adaptive immune response, which potentially can be exploited to detect and eliminate pathogenic objects. Consequently, numerous agonists that target TLRs are being used clinically either alone or in combination with other therapies to strengthen the immune system in the battle against cancer. This review summarizes the roles of TLRs in tumor biology, and focuses on relevant TLR-dependent antitumor pathways and the conjugation of TLR agonists as adjuvants to nano- and micro-particles for boosting responses leading to cancer suppression and eradication. STATEMENT OF SIGNIFICANCE: Toll-like receptors (TLRs), which express on antigen presenting cells, such as dendritic cells and macrophages, play an important role in sensing pathogenic agents and inducing adaptive immunity. As a result, several TLR agonists have been investigating as therapeutic agents individually or in combination with other treatment modalities for cancer treatment through boosting the immune system. This review aims to focus on the roles of TLRs in cancer and TLR-dependent antitumor pathways as well as the use of different nano- or micro-particles bearing TLR agonists for tumor inhibition and elimination." @default.
- W2945583619 created "2019-05-29" @default.
- W2945583619 creator A5026064781 @default.
- W2945583619 creator A5038396319 @default.
- W2945583619 creator A5054869693 @default.
- W2945583619 creator A5064088185 @default.
- W2945583619 creator A5083751923 @default.
- W2945583619 creator A5086090575 @default.
- W2945583619 creator A5089653227 @default.
- W2945583619 date "2019-08-01" @default.
- W2945583619 modified "2023-10-13" @default.
- W2945583619 title "Toll-like receptor-targeted particles: A paradigm to manipulate the tumor microenvironment for cancer immunotherapy" @default.
- W2945583619 cites W1508239850 @default.
- W2945583619 cites W1542274878 @default.
- W2945583619 cites W1603862958 @default.
- W2945583619 cites W1655860314 @default.
- W2945583619 cites W1917276580 @default.
- W2945583619 cites W1960585934 @default.
- W2945583619 cites W1964196894 @default.
- W2945583619 cites W1965118563 @default.
- W2945583619 cites W1965293768 @default.
- W2945583619 cites W1965917728 @default.
- W2945583619 cites W1970957701 @default.
- W2945583619 cites W1981015419 @default.
- W2945583619 cites W1984484036 @default.
- W2945583619 cites W1985476158 @default.
- W2945583619 cites W1991636753 @default.
- W2945583619 cites W1993442154 @default.
- W2945583619 cites W1995264219 @default.
- W2945583619 cites W1998250923 @default.
- W2945583619 cites W2004773897 @default.
- W2945583619 cites W2006617451 @default.
- W2945583619 cites W2007687296 @default.
- W2945583619 cites W2009834812 @default.
- W2945583619 cites W2010333332 @default.
- W2945583619 cites W2013262984 @default.
- W2945583619 cites W2015649564 @default.
- W2945583619 cites W2017045554 @default.
- W2945583619 cites W2023746601 @default.
- W2945583619 cites W2023797723 @default.
- W2945583619 cites W2033081825 @default.
- W2945583619 cites W2036895227 @default.
- W2945583619 cites W2037368492 @default.
- W2945583619 cites W2039461003 @default.
- W2945583619 cites W2041711928 @default.
- W2945583619 cites W2042814879 @default.
- W2945583619 cites W2043875007 @default.
- W2945583619 cites W2044835625 @default.
- W2945583619 cites W2048586712 @default.
- W2945583619 cites W2048941046 @default.
- W2945583619 cites W2049043684 @default.
- W2945583619 cites W2051912261 @default.
- W2945583619 cites W2051940924 @default.
- W2945583619 cites W2052434576 @default.
- W2945583619 cites W2055153091 @default.
- W2945583619 cites W2057874822 @default.
- W2945583619 cites W2058863496 @default.
- W2945583619 cites W2059422902 @default.
- W2945583619 cites W2060004514 @default.
- W2945583619 cites W2065114435 @default.
- W2945583619 cites W2066964346 @default.
- W2945583619 cites W2068975016 @default.
- W2945583619 cites W2069179045 @default.
- W2945583619 cites W2069592230 @default.
- W2945583619 cites W2070841458 @default.
- W2945583619 cites W2072632045 @default.
- W2945583619 cites W2076361525 @default.
- W2945583619 cites W2078057254 @default.
- W2945583619 cites W2082218262 @default.
- W2945583619 cites W2084880854 @default.
- W2945583619 cites W2087604357 @default.
- W2945583619 cites W2088228460 @default.
- W2945583619 cites W2088317237 @default.
- W2945583619 cites W2088599017 @default.
- W2945583619 cites W2097727405 @default.
- W2945583619 cites W2098263349 @default.
- W2945583619 cites W2101363646 @default.
- W2945583619 cites W2102403063 @default.
- W2945583619 cites W2103763724 @default.
- W2945583619 cites W2105894358 @default.
- W2945583619 cites W2109491705 @default.
- W2945583619 cites W2115542848 @default.
- W2945583619 cites W2120866805 @default.
- W2945583619 cites W2130687909 @default.
- W2945583619 cites W2131628814 @default.
- W2945583619 cites W2131811503 @default.
- W2945583619 cites W2132413371 @default.
- W2945583619 cites W2134724142 @default.
- W2945583619 cites W2137729498 @default.
- W2945583619 cites W2139918637 @default.
- W2945583619 cites W2143772132 @default.
- W2945583619 cites W2148707387 @default.
- W2945583619 cites W2158398996 @default.
- W2945583619 cites W2163919039 @default.
- W2945583619 cites W2165181124 @default.
- W2945583619 cites W2168240513 @default.
- W2945583619 cites W2172537925 @default.
- W2945583619 cites W2226509526 @default.