Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945586078> ?p ?o ?g. }
- W2945586078 endingPage "377" @default.
- W2945586078 startingPage "367" @default.
- W2945586078 abstract "Radium-223 dichloride ( 223 Ra) is the first, recently approved, α-particle-emitting radiopharmaceutical for the treatment of patients with bone metastases in castration-resistant prostate cancer (CRPC) and no evidence of visceral metastases. We explored MEDLINE, relevant congresses, and websites for data on 223 Ra and prostate cancer therapies, focusing on therapeutic strategies and timing, bone metastases, and diagnostic assessment. 223 Ra represents the only bone-targeting agent that has significantly extended patients’ overall survival while reducing pain and symptomatic skeletal events. Unlike other radiopharmaceuticals, such as strontium-89 and samarium-153 EDTMP, 223 Ra (11.4-days half-life) has shown a high biological efficiency mainly due to its short penetration range. These features potentially allow reduced bone marrow toxicity and limit undue exposure. 223 Ra has been validated under the product name Xofigo ® by the US Food and Drug Administration and the European Medicines Agency. Patient selection, management, and treatment sequencing is recommended to be discussed in the context of a multidisciplinary environment, including oncology, urology, nuclear medicine, and radiation therapy physicians. No consensus has been achieved regarding the optimal timing and its administration as single agent or in combination with zoledronic acid or chemotherapy, so far. This review aims to provide a rationale for the use of 223 Ra in treating metastases from CRPC, highlighting the crucial role of a multidisciplinary approach, the disputed inclusion and exclusion criteria on the basis of agencies regulations, and the value of diagnostics for therapy assessment." @default.
- W2945586078 created "2019-05-29" @default.
- W2945586078 creator A5019115297 @default.
- W2945586078 creator A5027458612 @default.
- W2945586078 creator A5040938414 @default.
- W2945586078 creator A5046454960 @default.
- W2945586078 creator A5078659753 @default.
- W2945586078 creator A5082981220 @default.
- W2945586078 creator A5087685517 @default.
- W2945586078 creator A5091677910 @default.
- W2945586078 date "2019-05-16" @default.
- W2945586078 modified "2023-10-18" @default.
- W2945586078 title "Radium-223 for the treatment of bone metastases in castration-resistant prostate cancer: when and why" @default.
- W2945586078 cites W1482356672 @default.
- W2945586078 cites W1517224081 @default.
- W2945586078 cites W1736083604 @default.
- W2945586078 cites W1907774037 @default.
- W2945586078 cites W1910380884 @default.
- W2945586078 cites W1995835470 @default.
- W2945586078 cites W2002045314 @default.
- W2945586078 cites W2018038855 @default.
- W2945586078 cites W2022687463 @default.
- W2945586078 cites W2039413693 @default.
- W2945586078 cites W2048150595 @default.
- W2945586078 cites W2065793218 @default.
- W2945586078 cites W2076668534 @default.
- W2945586078 cites W2083464054 @default.
- W2945586078 cites W2100074173 @default.
- W2945586078 cites W2103959341 @default.
- W2945586078 cites W2104923745 @default.
- W2945586078 cites W2109333569 @default.
- W2945586078 cites W2109768758 @default.
- W2945586078 cites W2111329225 @default.
- W2945586078 cites W2120292596 @default.
- W2945586078 cites W2123526148 @default.
- W2945586078 cites W2129444935 @default.
- W2945586078 cites W2135078918 @default.
- W2945586078 cites W2135375304 @default.
- W2945586078 cites W2136505615 @default.
- W2945586078 cites W2137467802 @default.
- W2945586078 cites W2141454098 @default.
- W2945586078 cites W2143165848 @default.
- W2945586078 cites W2144827656 @default.
- W2945586078 cites W2145018984 @default.
- W2945586078 cites W2147376175 @default.
- W2945586078 cites W2148643283 @default.
- W2945586078 cites W2156451504 @default.
- W2945586078 cites W2158639339 @default.
- W2945586078 cites W2161105336 @default.
- W2945586078 cites W2166305340 @default.
- W2945586078 cites W2168083201 @default.
- W2945586078 cites W2169636035 @default.
- W2945586078 cites W2170731023 @default.
- W2945586078 cites W2283896427 @default.
- W2945586078 cites W2293042402 @default.
- W2945586078 cites W2323231236 @default.
- W2945586078 cites W2582956935 @default.
- W2945586078 cites W2611848593 @default.
- W2945586078 cites W2735160137 @default.
- W2945586078 cites W2755661377 @default.
- W2945586078 cites W2767227550 @default.
- W2945586078 cites W2793400494 @default.
- W2945586078 cites W2799639295 @default.
- W2945586078 cites W4211234536 @default.
- W2945586078 doi "https://doi.org/10.1177/0300891619851376" @default.
- W2945586078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31096849" @default.
- W2945586078 hasPublicationYear "2019" @default.
- W2945586078 type Work @default.
- W2945586078 sameAs 2945586078 @default.
- W2945586078 citedByCount "18" @default.
- W2945586078 countsByYear W29455860782020 @default.
- W2945586078 countsByYear W29455860782021 @default.
- W2945586078 countsByYear W29455860782022 @default.
- W2945586078 countsByYear W29455860782023 @default.
- W2945586078 crossrefType "journal-article" @default.
- W2945586078 hasAuthorship W2945586078A5019115297 @default.
- W2945586078 hasAuthorship W2945586078A5027458612 @default.
- W2945586078 hasAuthorship W2945586078A5040938414 @default.
- W2945586078 hasAuthorship W2945586078A5046454960 @default.
- W2945586078 hasAuthorship W2945586078A5078659753 @default.
- W2945586078 hasAuthorship W2945586078A5082981220 @default.
- W2945586078 hasAuthorship W2945586078A5087685517 @default.
- W2945586078 hasAuthorship W2945586078A5091677910 @default.
- W2945586078 hasConcept C121608353 @default.
- W2945586078 hasConcept C126322002 @default.
- W2945586078 hasConcept C143998085 @default.
- W2945586078 hasConcept C151730666 @default.
- W2945586078 hasConcept C2776326535 @default.
- W2945586078 hasConcept C2777783956 @default.
- W2945586078 hasConcept C2779343474 @default.
- W2945586078 hasConcept C2780192828 @default.
- W2945586078 hasConcept C2780737065 @default.
- W2945586078 hasConcept C2781064419 @default.
- W2945586078 hasConcept C509974204 @default.
- W2945586078 hasConcept C71924100 @default.
- W2945586078 hasConcept C86803240 @default.
- W2945586078 hasConceptScore W2945586078C121608353 @default.
- W2945586078 hasConceptScore W2945586078C126322002 @default.