Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945586712> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2945586712 endingPage "9" @default.
- W2945586712 startingPage "4" @default.
- W2945586712 abstract "Background. Atherosclerosis is an inflammatory disease characterized by intense immunological activity, which immune responses participate in every phase of atherosclerosis. On fundamental importance in atherogenesis is nuclear factor-κB (NF- κB) that regulates activation of adhesion molecules (ICAM-1) and secretion of pro-inflammatory cytokines such as tumor necrosis factor (TNF-α) interleukin-1 (IL-1), and interleukin-6 (IL-6).Aims. The extract from pericarp of mangosteen (Garcinia mangostana Linn ) were carried out to investigate for anti-inflammatory activity in rat models with atherosclerosis.Methods. The subjects of the study were 30 albino rats of (Rattus novergicus Strain wistar), divided into 5 groups with six rats in each group. Group I comprises normal healthy rats remains untreated for 90 days;Group II comprises of high cholesterol diet induced atherosclerotic rats for 90 days; Group III, IV, and V comprise of high cholesterol diet induced atherosclerosis and were administered extract from pericarp of mangosteen orally (200mg/kg; 400 mg/kg, 800 mg/kg) daily for 90 days. After 90 days treatment, rats were decapitated and blood was sample collected from the aorta for determination level of TNF-α and IL-1 by ELISA. Aorta was taken to observe the expression of NF-kB, ICAM-1, and IL-6 using immunohistochemical techniques.Results. Oral administration (800 mg/kg) of the extract from pericarp of mangosteen significantly decreased the level of TNF-α, and IL-1 and also reduced the expression of NF-kB, ICAM-1, and IL-6.Conclusion. These results suggest that the extract from pericarp of mangosteen (Garcinia mangostana Linn)possess anti-inflammatory actions by reducing level of TNF-α, IL-1, and also reduce the expression of NF-kB, ICAM-1, and IL-6 that prevent the development of atherosclerosis." @default.
- W2945586712 created "2019-05-29" @default.
- W2945586712 creator A5003118707 @default.
- W2945586712 creator A5031542784 @default.
- W2945586712 creator A5089378930 @default.
- W2945586712 creator A5090224460 @default.
- W2945586712 date "2012-01-01" @default.
- W2945586712 modified "2023-09-27" @default.
- W2945586712 title "Effect of Extract from Pericarp of Mangosteen (Garcinia Mangostana Linn) as Anti-Inflammatory Agent in Rat Models with Atherosclerosis" @default.
- W2945586712 doi "https://doi.org/10.30701/ijc.v33i5.68" @default.
- W2945586712 hasPublicationYear "2012" @default.
- W2945586712 type Work @default.
- W2945586712 sameAs 2945586712 @default.
- W2945586712 citedByCount "0" @default.
- W2945586712 crossrefType "journal-article" @default.
- W2945586712 hasAuthorship W2945586712A5003118707 @default.
- W2945586712 hasAuthorship W2945586712A5031542784 @default.
- W2945586712 hasAuthorship W2945586712A5089378930 @default.
- W2945586712 hasAuthorship W2945586712A5090224460 @default.
- W2945586712 hasConcept C11988809 @default.
- W2945586712 hasConcept C126322002 @default.
- W2945586712 hasConcept C134018914 @default.
- W2945586712 hasConcept C16224149 @default.
- W2945586712 hasConcept C164027704 @default.
- W2945586712 hasConcept C17991360 @default.
- W2945586712 hasConcept C185592680 @default.
- W2945586712 hasConcept C185946421 @default.
- W2945586712 hasConcept C203014093 @default.
- W2945586712 hasConcept C2776914184 @default.
- W2945586712 hasConcept C2776985958 @default.
- W2945586712 hasConcept C2778163477 @default.
- W2945586712 hasConcept C2778690821 @default.
- W2945586712 hasConcept C2909826119 @default.
- W2945586712 hasConcept C556039675 @default.
- W2945586712 hasConcept C71924100 @default.
- W2945586712 hasConcept C74172505 @default.
- W2945586712 hasConcept C98274493 @default.
- W2945586712 hasConceptScore W2945586712C11988809 @default.
- W2945586712 hasConceptScore W2945586712C126322002 @default.
- W2945586712 hasConceptScore W2945586712C134018914 @default.
- W2945586712 hasConceptScore W2945586712C16224149 @default.
- W2945586712 hasConceptScore W2945586712C164027704 @default.
- W2945586712 hasConceptScore W2945586712C17991360 @default.
- W2945586712 hasConceptScore W2945586712C185592680 @default.
- W2945586712 hasConceptScore W2945586712C185946421 @default.
- W2945586712 hasConceptScore W2945586712C203014093 @default.
- W2945586712 hasConceptScore W2945586712C2776914184 @default.
- W2945586712 hasConceptScore W2945586712C2776985958 @default.
- W2945586712 hasConceptScore W2945586712C2778163477 @default.
- W2945586712 hasConceptScore W2945586712C2778690821 @default.
- W2945586712 hasConceptScore W2945586712C2909826119 @default.
- W2945586712 hasConceptScore W2945586712C556039675 @default.
- W2945586712 hasConceptScore W2945586712C71924100 @default.
- W2945586712 hasConceptScore W2945586712C74172505 @default.
- W2945586712 hasConceptScore W2945586712C98274493 @default.
- W2945586712 hasLocation W29455867121 @default.
- W2945586712 hasOpenAccess W2945586712 @default.
- W2945586712 hasPrimaryLocation W29455867121 @default.
- W2945586712 hasRelatedWork W1966223887 @default.
- W2945586712 hasRelatedWork W1966328785 @default.
- W2945586712 hasRelatedWork W2087620408 @default.
- W2945586712 hasRelatedWork W2353931128 @default.
- W2945586712 hasRelatedWork W2400710628 @default.
- W2945586712 hasRelatedWork W2474560145 @default.
- W2945586712 hasRelatedWork W2484704060 @default.
- W2945586712 hasRelatedWork W2515134605 @default.
- W2945586712 hasRelatedWork W2516796832 @default.
- W2945586712 hasRelatedWork W2809142686 @default.
- W2945586712 hasRelatedWork W2943575556 @default.
- W2945586712 hasRelatedWork W2965209357 @default.
- W2945586712 hasRelatedWork W2996470259 @default.
- W2945586712 hasRelatedWork W3012301692 @default.
- W2945586712 hasRelatedWork W3043519409 @default.
- W2945586712 hasRelatedWork W3084700264 @default.
- W2945586712 hasRelatedWork W3112953361 @default.
- W2945586712 hasRelatedWork W3134488275 @default.
- W2945586712 hasRelatedWork W3165384465 @default.
- W2945586712 hasRelatedWork W3197451992 @default.
- W2945586712 isParatext "false" @default.
- W2945586712 isRetracted "false" @default.
- W2945586712 magId "2945586712" @default.
- W2945586712 workType "article" @default.