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• W2945602729 abstract "What inhibits the inhibitors? In the hippocampus, each memory trace is encoded by a specific subset of pyramidal cells. The other pyramidal cells must be actively excluded from the memory encoding process by inhibition, which is done by selective dendrite-targeting interneurons. Szőnyi et al. found that γ-aminobutyric acid–releasing (GABAergic) cells located in a small region in the brain stem called the nucleus incertus project to the hippocampus. The nucleus incertus again is innervated by several regions that respond to salient stimuli. Its GABAergic cells preferentially inhibit the dendrite-targeting interneurons in the hippocampus. The nucleus incertus is thus a central mediator between brain regions that are highly responsive to salient stimuli and the hippocampal circuitry involved in memory formation. Science , this issue p. eaaw0445" @default.
• W2945602729 created "2019-05-29" @default.
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• W2945602729 date "2019-05-24" @default.
• W2945602729 modified "2023-10-16" @default.
• W2945602729 title "Brainstem nucleus incertus controls contextual memory formation" @default.
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• W2945602729 doi "https://doi.org/10.1126/science.aaw0445" @default.
• W2945602729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7210779" @default.

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