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- W2945604306 abstract "• Enzymatic futile cycle model is solved within the stochastic framework. • At thermodynamic limit, species probabilities follow universal Poisson distribution . • Normal distribution at large N limit is independent of thermodynamical parameters. • Noise, which can induce switching mechanism, could be a key regulating element. • The patterns of states driven by noise may correspond to distinct cellular states. The enzymatic futile cycle model, which is believe to regulate functional mechanism of bimolecular networks and associated signal processing, is solved analytically within the stochastic framework. The obtained probability distributions of substrate and product at stochastic to deterministic transition exhibit Poisson distribution, and with large ⟨ x ⟩ limit Normal distribution which are independent of thermodynamic variables indicating universal behavior of molecular distribution. The dynamics of the substrate and product, by simulating the reaction network using stochastic simulation algorithm , exhibit switching mechanism driven by noise in the system. We also observe various distinct noise driven patterns which may correspond to various cellular states. We propose that this noise induce switching mechanism and patterns could be a key element to regulate and control signal processing in molecular networks of cellular system, and may exhibit in the phenotype." @default.
- W2945604306 created "2019-05-29" @default.
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- W2945604306 date "2019-10-01" @default.
- W2945604306 modified "2023-10-09" @default.
- W2945604306 title "Universality in stochastic enzymatic futile cycle" @default.
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- W2945604306 doi "https://doi.org/10.1016/j.apm.2019.05.008" @default.
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