Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945607496> ?p ?o ?g. }
- W2945607496 endingPage "e15537" @default.
- W2945607496 startingPage "e15537" @default.
- W2945607496 abstract "The vast majority of acute promyelocytic leukemia (APL) is characterized with a specific chromosomal translocation t (15, 17) (q22, q21), which fuses PML-RARα leading to a good response to all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, there are few cases of atypical APL, including PLZF-RARα, F1P1L1-RARα, STAT5b-RARα, et al. Neither PLZF-RARα nor STAT5b-RARα are sensitive to ATRA and ATO, and the prognosis is poor.Here we have 3 cases (PLZF-RARα, n = 2; STAT5b-RARα, n = 1). Case A, A 53-year-old Chinese female had suffered ecchymosis in both legs for 3 days. Case B, A 44 years old male suffered pain from lower limbs and hip. Case C, 52-year-old male patient presented with fever for 3 weeks invalid to antibiotics and gingival bleeding for 1 week.With RT-PCR and karyotype, Case A is diagnosed with STAT5b-RARα-positive APL.Case B, C are diagnosed with PLZF-RARα-positive APL.In case A, ATO, and ATRA were used for induction treatment. In Case B, ATO, and chemotherapy with DA were given in the first induction treatment. In Case C, ATRA, and ATO were used immediately, subsequently, chemotherapy was added with DA, ATRA, and CAG combination treatment, and medium-dose cytarabine with daunorubicin were given regularly.In Case A, the patient refused the following treatment and discharged on day 25. In Case B, the patient got the disseminated intravascular coagulation (DIC).In Case C, the patient has survived for 7 months and remains CR.Both STAT5b-RARα-positive APL and PLZF-RARα-positive APL appear to be resistant to both ATRA and ATO, so combined chemotherapy and allo-HSCT should be considered. Since the prognosis and long-term outcome are poor, more clinical trials, and researches should be taken." @default.
- W2945607496 created "2019-05-29" @default.
- W2945607496 creator A5031545775 @default.
- W2945607496 creator A5037677450 @default.
- W2945607496 creator A5081589298 @default.
- W2945607496 date "2019-05-01" @default.
- W2945607496 modified "2023-10-12" @default.
- W2945607496 title "Characterization of atypical acute promyelocytic leukaemia" @default.
- W2945607496 cites W1553407386 @default.
- W2945607496 cites W1553544241 @default.
- W2945607496 cites W1555644831 @default.
- W2945607496 cites W1806091569 @default.
- W2945607496 cites W1837808839 @default.
- W2945607496 cites W1976165544 @default.
- W2945607496 cites W1981347116 @default.
- W2945607496 cites W1982006019 @default.
- W2945607496 cites W1992842669 @default.
- W2945607496 cites W1999758327 @default.
- W2945607496 cites W2003276132 @default.
- W2945607496 cites W2004742920 @default.
- W2945607496 cites W2008513160 @default.
- W2945607496 cites W2013532484 @default.
- W2945607496 cites W2024885194 @default.
- W2945607496 cites W2026556815 @default.
- W2945607496 cites W2032650747 @default.
- W2945607496 cites W2035107475 @default.
- W2945607496 cites W2045648601 @default.
- W2945607496 cites W2059336725 @default.
- W2945607496 cites W2060499086 @default.
- W2945607496 cites W2073314392 @default.
- W2945607496 cites W2096603155 @default.
- W2945607496 cites W2111504523 @default.
- W2945607496 cites W2134429215 @default.
- W2945607496 cites W2135898904 @default.
- W2945607496 cites W2143279907 @default.
- W2945607496 cites W2153773817 @default.
- W2945607496 cites W2161555850 @default.
- W2945607496 cites W2174247300 @default.
- W2945607496 cites W2254208418 @default.
- W2945607496 cites W2280629315 @default.
- W2945607496 cites W2289598688 @default.
- W2945607496 cites W2414626961 @default.
- W2945607496 cites W2742021016 @default.
- W2945607496 cites W3024671475 @default.
- W2945607496 cites W6670230 @default.
- W2945607496 doi "https://doi.org/10.1097/md.0000000000015537" @default.
- W2945607496 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6531224" @default.
- W2945607496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31083206" @default.
- W2945607496 hasPublicationYear "2019" @default.
- W2945607496 type Work @default.
- W2945607496 sameAs 2945607496 @default.
- W2945607496 citedByCount "5" @default.
- W2945607496 countsByYear W29456074962019 @default.
- W2945607496 countsByYear W29456074962020 @default.
- W2945607496 countsByYear W29456074962021 @default.
- W2945607496 crossrefType "journal-article" @default.
- W2945607496 hasAuthorship W2945607496A5031545775 @default.
- W2945607496 hasAuthorship W2945607496A5037677450 @default.
- W2945607496 hasAuthorship W2945607496A5081589298 @default.
- W2945607496 hasBestOaLocation W29456074961 @default.
- W2945607496 hasConcept C104317684 @default.
- W2945607496 hasConcept C126322002 @default.
- W2945607496 hasConcept C141071460 @default.
- W2945607496 hasConcept C185592680 @default.
- W2945607496 hasConcept C190283241 @default.
- W2945607496 hasConcept C2776601000 @default.
- W2945607496 hasConcept C2776611710 @default.
- W2945607496 hasConcept C2776694085 @default.
- W2945607496 hasConcept C2778041864 @default.
- W2945607496 hasConcept C2778734968 @default.
- W2945607496 hasConcept C2779117419 @default.
- W2945607496 hasConcept C2779663748 @default.
- W2945607496 hasConcept C2780386689 @default.
- W2945607496 hasConcept C2781121885 @default.
- W2945607496 hasConcept C55493867 @default.
- W2945607496 hasConcept C71924100 @default.
- W2945607496 hasConcept C90924648 @default.
- W2945607496 hasConceptScore W2945607496C104317684 @default.
- W2945607496 hasConceptScore W2945607496C126322002 @default.
- W2945607496 hasConceptScore W2945607496C141071460 @default.
- W2945607496 hasConceptScore W2945607496C185592680 @default.
- W2945607496 hasConceptScore W2945607496C190283241 @default.
- W2945607496 hasConceptScore W2945607496C2776601000 @default.
- W2945607496 hasConceptScore W2945607496C2776611710 @default.
- W2945607496 hasConceptScore W2945607496C2776694085 @default.
- W2945607496 hasConceptScore W2945607496C2778041864 @default.
- W2945607496 hasConceptScore W2945607496C2778734968 @default.
- W2945607496 hasConceptScore W2945607496C2779117419 @default.
- W2945607496 hasConceptScore W2945607496C2779663748 @default.
- W2945607496 hasConceptScore W2945607496C2780386689 @default.
- W2945607496 hasConceptScore W2945607496C2781121885 @default.
- W2945607496 hasConceptScore W2945607496C55493867 @default.
- W2945607496 hasConceptScore W2945607496C71924100 @default.
- W2945607496 hasConceptScore W2945607496C90924648 @default.
- W2945607496 hasIssue "19" @default.
- W2945607496 hasLocation W29456074961 @default.
- W2945607496 hasLocation W29456074962 @default.
- W2945607496 hasLocation W29456074963 @default.