Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945607684> ?p ?o ?g. }
- W2945607684 abstract "The acidic patch is a functionally important epitope on each face of the nucleosome that affects chromatin remodeling. Although related by 2-fold symmetry of the nucleosome, each acidic patch is uniquely positioned relative to a bound remodeler. An open question is whether remodelers are distinctly responsive to each acidic patch. Previously we reported a method for homogeneously producing asymmetric nucleosomes with distinct H2A/H2B dimers (Levendosky et al., 2016). Here, we use this methodology to show that the Chd1 remodeler from Saccharomyces cerevisiae and ISWI remodelers from human and Drosophila have distinct spatial requirements for the acidic patch. Unlike Chd1, which is equally affected by entry- and exit-side mutations, ISWI remodelers strongly depend on the entry-side acidic patch. Remarkably, asymmetry in the two acidic patches stimulates ISWI to slide mononucleosomes off DNA ends, overriding the remodeler’s preference to shift the histone core toward longer flanking DNA." @default.
- W2945607684 created "2019-05-29" @default.
- W2945607684 creator A5031181291 @default.
- W2945607684 creator A5079913046 @default.
- W2945607684 date "2019-05-16" @default.
- W2945607684 modified "2023-10-17" @default.
- W2945607684 title "Asymmetry between the two acidic patches dictates the direction of nucleosome sliding by the ISWI chromatin remodeler" @default.
- W2945607684 cites W134483022 @default.
- W2945607684 cites W1546616884 @default.
- W2945607684 cites W1571482483 @default.
- W2945607684 cites W1965200310 @default.
- W2945607684 cites W1973536007 @default.
- W2945607684 cites W1981048910 @default.
- W2945607684 cites W1988997227 @default.
- W2945607684 cites W1989325752 @default.
- W2945607684 cites W1995782808 @default.
- W2945607684 cites W1999201519 @default.
- W2945607684 cites W2008944022 @default.
- W2945607684 cites W2011958170 @default.
- W2945607684 cites W2013925438 @default.
- W2945607684 cites W2020582422 @default.
- W2945607684 cites W2022237004 @default.
- W2945607684 cites W2029136195 @default.
- W2945607684 cites W2029472359 @default.
- W2945607684 cites W2029836146 @default.
- W2945607684 cites W2031073218 @default.
- W2945607684 cites W2044946046 @default.
- W2945607684 cites W2051104214 @default.
- W2945607684 cites W2053322986 @default.
- W2945607684 cites W2065123158 @default.
- W2945607684 cites W2068994422 @default.
- W2945607684 cites W2069328568 @default.
- W2945607684 cites W2077319657 @default.
- W2945607684 cites W2079685157 @default.
- W2945607684 cites W2081032844 @default.
- W2945607684 cites W2084424064 @default.
- W2945607684 cites W2089456111 @default.
- W2945607684 cites W2092668333 @default.
- W2945607684 cites W2100239410 @default.
- W2945607684 cites W2112013199 @default.
- W2945607684 cites W2114030147 @default.
- W2945607684 cites W2118342658 @default.
- W2945607684 cites W2131497564 @default.
- W2945607684 cites W2131838202 @default.
- W2945607684 cites W2144792857 @default.
- W2945607684 cites W2144874189 @default.
- W2945607684 cites W2151553287 @default.
- W2945607684 cites W2156101468 @default.
- W2945607684 cites W2158930155 @default.
- W2945607684 cites W2167284666 @default.
- W2945607684 cites W2171859829 @default.
- W2945607684 cites W2292967495 @default.
- W2945607684 cites W2353162679 @default.
- W2945607684 cites W2530956344 @default.
- W2945607684 cites W2574624783 @default.
- W2945607684 cites W2587703700 @default.
- W2945607684 cites W2614855056 @default.
- W2945607684 cites W2741989799 @default.
- W2945607684 cites W2756786203 @default.
- W2945607684 cites W2762613271 @default.
- W2945607684 cites W2795042203 @default.
- W2945607684 cites W2799984503 @default.
- W2945607684 doi "https://doi.org/10.7554/elife.45472" @default.
- W2945607684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6546392" @default.
- W2945607684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31094676" @default.
- W2945607684 hasPublicationYear "2019" @default.
- W2945607684 type Work @default.
- W2945607684 sameAs 2945607684 @default.
- W2945607684 citedByCount "31" @default.
- W2945607684 countsByYear W29456076842019 @default.
- W2945607684 countsByYear W29456076842020 @default.
- W2945607684 countsByYear W29456076842021 @default.
- W2945607684 countsByYear W29456076842022 @default.
- W2945607684 countsByYear W29456076842023 @default.
- W2945607684 crossrefType "journal-article" @default.
- W2945607684 hasAuthorship W2945607684A5031181291 @default.
- W2945607684 hasAuthorship W2945607684A5079913046 @default.
- W2945607684 hasBestOaLocation W29456076841 @default.
- W2945607684 hasConcept C104317684 @default.
- W2945607684 hasConcept C12554922 @default.
- W2945607684 hasConcept C167227067 @default.
- W2945607684 hasConcept C185592680 @default.
- W2945607684 hasConcept C193646685 @default.
- W2945607684 hasConcept C2777576037 @default.
- W2945607684 hasConcept C54355233 @default.
- W2945607684 hasConcept C552990157 @default.
- W2945607684 hasConcept C55493867 @default.
- W2945607684 hasConcept C64927066 @default.
- W2945607684 hasConcept C83640560 @default.
- W2945607684 hasConcept C84772758 @default.
- W2945607684 hasConcept C86803240 @default.
- W2945607684 hasConcept C95444343 @default.
- W2945607684 hasConceptScore W2945607684C104317684 @default.
- W2945607684 hasConceptScore W2945607684C12554922 @default.
- W2945607684 hasConceptScore W2945607684C167227067 @default.
- W2945607684 hasConceptScore W2945607684C185592680 @default.
- W2945607684 hasConceptScore W2945607684C193646685 @default.
- W2945607684 hasConceptScore W2945607684C2777576037 @default.
- W2945607684 hasConceptScore W2945607684C54355233 @default.
- W2945607684 hasConceptScore W2945607684C552990157 @default.