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- W2945612886 abstract "Natural products provide the inspiration for most clinical drugs. With the rise in antibiotic resistance, it is imperative to discover new sources of chemical diversity. Bacteria living in symbiosis with marine invertebrates have emerged as an untapped source of natural chemistry. While symbiotic bacteria are often recalcitrant to growth in the lab, advances in metagenomic sequencing and assembly now make it possible to access their genetic blueprint. A cell enrichment procedure, combined with a hybrid sequencing and assembly approach, enabled detailed genomic analysis of uncultivated cyanobacterial symbiont populations in two chemically rich tropical marine sponges. These population genomes reveal a wealth of secondary metabolism potential as well as possible reasons for historical difficulties in their cultivation." @default.
- W2945612886 created "2019-05-29" @default.
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- W2945612886 date "2019-06-25" @default.
- W2945612886 modified "2023-09-30" @default.
- W2945612886 title "Comparative Genomics of Cyanobacterial Symbionts Reveals Distinct, Specialized Metabolism in Tropical <i>Dysideidae</i> Sponges" @default.
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- W2945612886 doi "https://doi.org/10.1128/mbio.00821-19" @default.
- W2945612886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6520454" @default.
- W2945612886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31088928" @default.
- W2945612886 hasPublicationYear "2019" @default.
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