Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945613580> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2945613580 abstract "Purpose/Objectives: The TRANSLATE project started in 2016 to test the immune effects of metronomic cyclophosphamide, daily low-dose IL-2 every other week, and a single flash of radiotherapy (RT) in peripheral blood. The rationale is based on self vaccination induced by radiotherapy (RT) 8 Gy single fraction on one metastatic lesion, T cells expansion by IL-2 treatment and selective Tregs down regulation by lowdose cyclophosphamide administration.Materials/Methods: We enrolled patients with end-stage breast, colon, kidney and prostate cancer. Analysis was performed at baseline, the day after RT, after 28 days from treatment start and at disease progression. Assay focused on Tregs, CD8+, NK, MDSC, CD3-PD1, IL-2, IL-4, IL-5, IL- 6, IL-10, IL-12, IL-13, IL-17a, TNFα, IFNγ, TGFβ. We divided patients into two groups depending on the time of disease progression (A > 3 months; B, < 3 months). We report preliminary data with the aim to show the changes observed post-RT in 20 pts.Results: At baseline, group B had higher rates of CD3-PD1, higher IL-2, IL-13, TNFα, and TGFβ; group A had higher IFN γ, IL-4, and IL-12. After RT, we observed a difference between the two groups in the rates of CD3-PD1 (lower in group B) and Tregs (higher in group A). Among cytokines, only TNFα reached a statistical significance (higher in group B). We also observed that TGFβ and IL-6 were higher in group B and IFNγ was higher in group A. The longitudinal analyses showed that CD3-PD1 remained stable between basal and post-RT in group A but decreased in group B. Tregs marginally increased in group A. TNFα, TGFβ, IL-4, IL-6, and IL-12 increased in group B. IL-4 decreased in group A and IL-6 and IL-12 also marginally decreased in the same group. IFNγ slightly increases in group A. Discussion: The limited number of patients reduced the interpretation of the study. However, following RT a positive trend of Th2 cytokines is observed in patients with early progressing disease, without the expected surge of IFNγ that was instead observed in patients with better outcome. Additional analyses are in progress and will be presented." @default.
- W2945613580 created "2019-05-29" @default.
- W2945613580 creator A5006953403 @default.
- W2945613580 creator A5008151170 @default.
- W2945613580 creator A5009199625 @default.
- W2945613580 creator A5011010900 @default.
- W2945613580 creator A5015046932 @default.
- W2945613580 creator A5017619486 @default.
- W2945613580 creator A5021709418 @default.
- W2945613580 creator A5041240875 @default.
- W2945613580 creator A5050361464 @default.
- W2945613580 creator A5067901389 @default.
- W2945613580 creator A5072883486 @default.
- W2945613580 creator A5076325009 @default.
- W2945613580 creator A5087702698 @default.
- W2945613580 date "2018-11-04" @default.
- W2945613580 modified "2023-09-23" @default.
- W2945613580 title "Activation of immune response in refractory patients to standard treatment (T.R.A.N.S.L.A.T.E.)" @default.
- W2945613580 doi "https://doi.org/10.18416/cio.2018.1810052" @default.
- W2945613580 hasPublicationYear "2018" @default.
- W2945613580 type Work @default.
- W2945613580 sameAs 2945613580 @default.
- W2945613580 citedByCount "0" @default.
- W2945613580 crossrefType "journal-article" @default.
- W2945613580 hasAuthorship W2945613580A5006953403 @default.
- W2945613580 hasAuthorship W2945613580A5008151170 @default.
- W2945613580 hasAuthorship W2945613580A5009199625 @default.
- W2945613580 hasAuthorship W2945613580A5011010900 @default.
- W2945613580 hasAuthorship W2945613580A5015046932 @default.
- W2945613580 hasAuthorship W2945613580A5017619486 @default.
- W2945613580 hasAuthorship W2945613580A5021709418 @default.
- W2945613580 hasAuthorship W2945613580A5041240875 @default.
- W2945613580 hasAuthorship W2945613580A5050361464 @default.
- W2945613580 hasAuthorship W2945613580A5067901389 @default.
- W2945613580 hasAuthorship W2945613580A5072883486 @default.
- W2945613580 hasAuthorship W2945613580A5076325009 @default.
- W2945613580 hasAuthorship W2945613580A5087702698 @default.
- W2945613580 hasConcept C126322002 @default.
- W2945613580 hasConcept C143998085 @default.
- W2945613580 hasConcept C167672396 @default.
- W2945613580 hasConcept C203014093 @default.
- W2945613580 hasConcept C2776694085 @default.
- W2945613580 hasConcept C2776755627 @default.
- W2945613580 hasConcept C2777785397 @default.
- W2945613580 hasConcept C2778690821 @default.
- W2945613580 hasConcept C71924100 @default.
- W2945613580 hasConcept C8891405 @default.
- W2945613580 hasConcept C90924648 @default.
- W2945613580 hasConceptScore W2945613580C126322002 @default.
- W2945613580 hasConceptScore W2945613580C143998085 @default.
- W2945613580 hasConceptScore W2945613580C167672396 @default.
- W2945613580 hasConceptScore W2945613580C203014093 @default.
- W2945613580 hasConceptScore W2945613580C2776694085 @default.
- W2945613580 hasConceptScore W2945613580C2776755627 @default.
- W2945613580 hasConceptScore W2945613580C2777785397 @default.
- W2945613580 hasConceptScore W2945613580C2778690821 @default.
- W2945613580 hasConceptScore W2945613580C71924100 @default.
- W2945613580 hasConceptScore W2945613580C8891405 @default.
- W2945613580 hasConceptScore W2945613580C90924648 @default.
- W2945613580 hasIssue "1" @default.
- W2945613580 hasLocation W29456135801 @default.
- W2945613580 hasOpenAccess W2945613580 @default.
- W2945613580 hasPrimaryLocation W29456135801 @default.
- W2945613580 hasRelatedWork W2031029868 @default.
- W2945613580 hasRelatedWork W2323940822 @default.
- W2945613580 hasRelatedWork W2333628568 @default.
- W2945613580 hasRelatedWork W2356783367 @default.
- W2945613580 hasRelatedWork W2361283026 @default.
- W2945613580 hasRelatedWork W2369890757 @default.
- W2945613580 hasRelatedWork W2370955571 @default.
- W2945613580 hasRelatedWork W2382062140 @default.
- W2945613580 hasRelatedWork W2388983852 @default.
- W2945613580 hasRelatedWork W2460131066 @default.
- W2945613580 hasRelatedWork W2521972840 @default.
- W2945613580 hasRelatedWork W2567390976 @default.
- W2945613580 hasRelatedWork W2583241764 @default.
- W2945613580 hasRelatedWork W2794363653 @default.
- W2945613580 hasRelatedWork W2950064282 @default.
- W2945613580 hasRelatedWork W2980799039 @default.
- W2945613580 hasRelatedWork W3000060247 @default.
- W2945613580 hasRelatedWork W3032024436 @default.
- W2945613580 hasRelatedWork W3044124561 @default.
- W2945613580 hasRelatedWork W3199809470 @default.
- W2945613580 hasVolume "1" @default.
- W2945613580 isParatext "false" @default.
- W2945613580 isRetracted "false" @default.
- W2945613580 magId "2945613580" @default.
- W2945613580 workType "article" @default.