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- W2945631444 endingPage "1239" @default.
- W2945631444 startingPage "1229" @default.
- W2945631444 abstract "Blood coagulation factor Va serves an indispensable role in hemostasis as cofactor for the serine protease factor Xa. In the presence of an anionic phospholipid membrane and calcium ions, factors Va and Xa assemble into the prothrombinase complex. Following formation of the ternary complex with the macromolecular zymogen substrate prothrombin, the latter is rapidly converted into thrombin, the key regulatory enzyme of coagulation. Over the years, multiple binding sites have been identified in factor Va that play a role in the interaction of the cofactor with factor Xa, prothrombin, or the anionic phospholipid membrane surface. In this review, an overview of the currently available information on these interactive sites in factor Va is provided, and data from biochemical approaches and 3D structural protein complex models are discussed. The structural models have been generated in recent years and provide novel insights into the molecular requirements for assembly of both the prothrombinase and the ternary prothrombinase‐prothrombin complexes. Integrated knowledge of functionally important regions in factor Va will allow for a better understanding of factor Va cofactor activity." @default.
- W2945631444 created "2019-05-29" @default.
- W2945631444 creator A5016524733 @default.
- W2945631444 creator A5057396192 @default.
- W2945631444 creator A5065737966 @default.
- W2945631444 date "2019-08-01" @default.
- W2945631444 modified "2023-09-30" @default.
- W2945631444 title "Blood coagulation factor Va's key interactive residues and regions for prothrombinase assembly and prothrombin binding" @default.
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