Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945631985> ?p ?o ?g. }
- W2945631985 endingPage "324" @default.
- W2945631985 startingPage "318" @default.
- W2945631985 abstract "Purpose of review In the absence of a protective vaccine against HIV-1, passive immunization using novel broadly neutralizing antibodies (bNAbs) is an attractive concept for HIV-1 prevention. Here, we summarize the results of preclinical and clinical studies of bNAbs, discuss strategies for optimizing bNAb efficacy and lay out current pathways for the development of bNAbs as prophylaxis. Recent findings Passive transfer of second-generation bNAbs results inpotent protection against infection in preclinical animal models. Furthermore, multiple bNAbs targeting different epitopes on the HIV-1 envelope trimer are in clinical evaluation and have demonstrated favorable safety profiles and robust antiviral activity in chronically infected individuals. The confirmation that passive immunization with bNAb(s) will prevent HIV-1 acquisition in humans is pending and the focus of ongoing investigations. Given the global diversity of HIV-1, bNAb combinations or multispecific antibodies will most likely be required to produce the necessary breadth for effective protection. Summary Encouraging results from preclinical and clinical studies support the development of bNAbs for prevention and a number of antibodies with exceptional breadth and potency are available for clinical evaluation. Further optimization of viral coverage and antibody half-life will accelerate the clinical implementation of bNAbs as a critical tool for HIV-1 prevention strategies." @default.
- W2945631985 created "2019-05-29" @default.
- W2945631985 creator A5054247332 @default.
- W2945631985 creator A5076217842 @default.
- W2945631985 date "2019-07-01" @default.
- W2945631985 modified "2023-10-16" @default.
- W2945631985 title "Neutralizing antibodies for HIV-1 prevention" @default.
- W2945631985 cites W1528520360 @default.
- W2945631985 cites W1533750546 @default.
- W2945631985 cites W1594804329 @default.
- W2945631985 cites W1623081601 @default.
- W2945631985 cites W1794879226 @default.
- W2945631985 cites W1818776176 @default.
- W2945631985 cites W1924338894 @default.
- W2945631985 cites W1964903237 @default.
- W2945631985 cites W1965439127 @default.
- W2945631985 cites W1974431423 @default.
- W2945631985 cites W1979162895 @default.
- W2945631985 cites W1983538138 @default.
- W2945631985 cites W1985136634 @default.
- W2945631985 cites W1988781661 @default.
- W2945631985 cites W1990745725 @default.
- W2945631985 cites W1992529182 @default.
- W2945631985 cites W1993675648 @default.
- W2945631985 cites W1994933959 @default.
- W2945631985 cites W1998683102 @default.
- W2945631985 cites W2005044790 @default.
- W2945631985 cites W2008602151 @default.
- W2945631985 cites W2018123062 @default.
- W2945631985 cites W2024287923 @default.
- W2945631985 cites W2026245568 @default.
- W2945631985 cites W2030129290 @default.
- W2945631985 cites W2038110764 @default.
- W2945631985 cites W2045136276 @default.
- W2945631985 cites W2052938525 @default.
- W2945631985 cites W2053452332 @default.
- W2945631985 cites W2056477077 @default.
- W2945631985 cites W2070086938 @default.
- W2945631985 cites W2070258047 @default.
- W2945631985 cites W2073383703 @default.
- W2945631985 cites W2083726777 @default.
- W2945631985 cites W2098013141 @default.
- W2945631985 cites W2105208620 @default.
- W2945631985 cites W2108422942 @default.
- W2945631985 cites W2113236498 @default.
- W2945631985 cites W2113822425 @default.
- W2945631985 cites W2118274231 @default.
- W2945631985 cites W2127635055 @default.
- W2945631985 cites W2134087536 @default.
- W2945631985 cites W2135151522 @default.
- W2945631985 cites W2143421242 @default.
- W2945631985 cites W2145067766 @default.
- W2945631985 cites W2146943626 @default.
- W2945631985 cites W2158498221 @default.
- W2945631985 cites W2159515958 @default.
- W2945631985 cites W2161169821 @default.
- W2945631985 cites W2171478268 @default.
- W2945631985 cites W2200798239 @default.
- W2945631985 cites W2229789789 @default.
- W2945631985 cites W2272960839 @default.
- W2945631985 cites W2294858472 @default.
- W2945631985 cites W2308542537 @default.
- W2945631985 cites W2324835369 @default.
- W2945631985 cites W2343862396 @default.
- W2945631985 cites W2346116821 @default.
- W2945631985 cites W2347047438 @default.
- W2945631985 cites W2415277045 @default.
- W2945631985 cites W2426635085 @default.
- W2945631985 cites W2460321387 @default.
- W2945631985 cites W2462486714 @default.
- W2945631985 cites W2467571498 @default.
- W2945631985 cites W2473595575 @default.
- W2945631985 cites W2479380438 @default.
- W2945631985 cites W2508401215 @default.
- W2945631985 cites W2551273870 @default.
- W2945631985 cites W2567494367 @default.
- W2945631985 cites W2572760626 @default.
- W2945631985 cites W2580378056 @default.
- W2945631985 cites W2581209976 @default.
- W2945631985 cites W2582676572 @default.
- W2945631985 cites W2597074085 @default.
- W2945631985 cites W2616719177 @default.
- W2945631985 cites W2743997698 @default.
- W2945631985 cites W2747040076 @default.
- W2945631985 cites W2751251539 @default.
- W2945631985 cites W2754021327 @default.
- W2945631985 cites W2755090825 @default.
- W2945631985 cites W2775401818 @default.
- W2945631985 cites W2802584574 @default.
- W2945631985 cites W2803410236 @default.
- W2945631985 cites W2804865139 @default.
- W2945631985 cites W2892753696 @default.
- W2945631985 cites W2897595682 @default.
- W2945631985 cites W2909011032 @default.
- W2945631985 doi "https://doi.org/10.1097/coh.0000000000000556" @default.
- W2945631985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7341949" @default.
- W2945631985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31082819" @default.
- W2945631985 hasPublicationYear "2019" @default.