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- W2945641018 abstract "In the present work, a method for the simultaneous enantioselective separation of bupropion (BUP) and hydroxybupropion (HBUP) by capillary electrophoresis (CE) was developed. After the optimization process, the best results found were: 75 mmol L−1 phosphate BGE at pH 7.0; 4.0 mg mL−1 for the sulfated-ß-cyclodextrin (S-β-CD). This experimental protocol provided the best resolution values (Rs1 = 2.06, Rs2 = 5.62 and Rs3 = 6.68). From the theoretical calculations, based on the energetic and structural obtained results, it was possible to point out, on the molecular level, the migration order of BUP and HBUP enantiomers." @default.
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- W2945641018 date "2019-09-01" @default.
- W2945641018 modified "2023-10-17" @default.
- W2945641018 title "Enantioselective separation of bupropion and its major metabolite hydroxybupropion: An experimental and theoretical study" @default.
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- W2945641018 doi "https://doi.org/10.1016/j.cplett.2019.05.035" @default.
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