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- W2945641515 abstract "Aim: A sensitive and selective ultra performance LC–MS/MS (UPLC–MS/MS) method was developed to investigate the pharmacokinetics of rosavin as a potential adaptogenic drug isolated from Rhodiola rosa L. in rat plasma with salidroside as an internal standard. Methodology: Chromatographic separation was performed on a UPLC HSS T3 column (1.8 μm, 100 mm × 2.1 mm) with gradient elution. Multiple reaction monitoring was employed for MS analysis. Rosavin and salidroside were determined with multiple reaction monitoring–ion transitions m/z 427.2 → 293.1 and m/z 299.1 → 119.1, respectively. Conclusion: The validated UPLC–MS/MS method showed a satisfied linear range in 5–5000 ng/ml -1 and was successfully applied for the pharmacokinetic study of rosavin in the rat after intravenous and gavage administration." @default.
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- W2945641515 date "2019-05-01" @default.
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- W2945641515 title "Pharmacokinetic study of rosavin in rat plasma with ultra performance LC–MS/MS after intravenous and gavage administration" @default.
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- W2945641515 doi "https://doi.org/10.4155/bio-2019-0022" @default.
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