Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945642997> ?p ?o ?g. }
- W2945642997 endingPage "263" @default.
- W2945642997 startingPage "250" @default.
- W2945642997 abstract "We discuss recent discoveries in hypoxic cellular pathophysiology and explore the interplay between hypoxic malignant cells and other stromal elements. This review will provide an update on the effects of hypoxia on cancer outcomes and therapeutic resistance.Hypoxia has been discovered to be a key driver for tumor progression, both because of impacts on tumor cells and separately on the wider tumor microenvironment. The latter effects occur via epithelial mesenchymal transition, autophagy and metabolic switching. Through epithelial mesenchymal transition, hypoxia both drives metastasis and renders key target tissues receptive to metastasis. Autophagy is a double-edged sword which requires greater understanding to ascertain when it is a threat. Metabolic switching allows tumor cells to access hypoxic survival mechanisms even under normoxic conditions.Every element of the malignant stroma contributes to hypoxia-driven progression. Exosomal transfer of molecules from hypoxic tumor cells to target stromal cell types and the importance of microRNAs in intercellular communication have emerged as key themes.Antiangiogenic resistance can be caused by hypoxia-driven vasculogenic mimicry. Beyond this, hypoxia contributes to resistance to virtually all oncological treatment modalities.Recent advances have moved us closer to being able to exploit hypoxic mechanisms to overcome hypoxia-driven progression and therapy failure." @default.
- W2945642997 created "2019-05-29" @default.
- W2945642997 creator A5004957581 @default.
- W2945642997 creator A5007156981 @default.
- W2945642997 creator A5029344208 @default.
- W2945642997 date "2019-07-01" @default.
- W2945642997 modified "2023-10-16" @default.
- W2945642997 title "Hypoxia as a signal for prison breakout in cancer" @default.
- W2945642997 cites W1503667331 @default.
- W2945642997 cites W1605172632 @default.
- W2945642997 cites W1817551500 @default.
- W2945642997 cites W1920936157 @default.
- W2945642997 cites W1963719232 @default.
- W2945642997 cites W1973599157 @default.
- W2945642997 cites W1979323646 @default.
- W2945642997 cites W1981182976 @default.
- W2945642997 cites W1981487137 @default.
- W2945642997 cites W1999133016 @default.
- W2945642997 cites W1999251458 @default.
- W2945642997 cites W2000642539 @default.
- W2945642997 cites W2008416894 @default.
- W2945642997 cites W2009177545 @default.
- W2945642997 cites W2011272270 @default.
- W2945642997 cites W2018011096 @default.
- W2945642997 cites W2021381932 @default.
- W2945642997 cites W2033363278 @default.
- W2945642997 cites W2060628991 @default.
- W2945642997 cites W2088590657 @default.
- W2945642997 cites W2089193076 @default.
- W2945642997 cites W2103311860 @default.
- W2945642997 cites W2121744013 @default.
- W2945642997 cites W2124496728 @default.
- W2945642997 cites W2139128338 @default.
- W2945642997 cites W2157607856 @default.
- W2945642997 cites W2160670827 @default.
- W2945642997 cites W2165036434 @default.
- W2945642997 cites W2175261477 @default.
- W2945642997 cites W2180681455 @default.
- W2945642997 cites W2511897228 @default.
- W2945642997 cites W2522447413 @default.
- W2945642997 cites W2531574904 @default.
- W2945642997 cites W2531719869 @default.
- W2945642997 cites W2555713683 @default.
- W2945642997 cites W2557827074 @default.
- W2945642997 cites W2560540869 @default.
- W2945642997 cites W2564408837 @default.
- W2945642997 cites W2574610998 @default.
- W2945642997 cites W2576512904 @default.
- W2945642997 cites W2580568552 @default.
- W2945642997 cites W2585581952 @default.
- W2945642997 cites W2591765352 @default.
- W2945642997 cites W2593897082 @default.
- W2945642997 cites W2594476307 @default.
- W2945642997 cites W2601830769 @default.
- W2945642997 cites W2608168866 @default.
- W2945642997 cites W2608932173 @default.
- W2945642997 cites W2611163072 @default.
- W2945642997 cites W2613939444 @default.
- W2945642997 cites W2614547849 @default.
- W2945642997 cites W2614787430 @default.
- W2945642997 cites W2615737356 @default.
- W2945642997 cites W2616225440 @default.
- W2945642997 cites W2616588657 @default.
- W2945642997 cites W2625195958 @default.
- W2945642997 cites W2651532071 @default.
- W2945642997 cites W2724106870 @default.
- W2945642997 cites W2734955833 @default.
- W2945642997 cites W2743002242 @default.
- W2945642997 cites W2744183651 @default.
- W2945642997 cites W2747169154 @default.
- W2945642997 cites W2753778372 @default.
- W2945642997 cites W2755103617 @default.
- W2945642997 cites W2757463163 @default.
- W2945642997 cites W2764019302 @default.
- W2945642997 cites W2767326639 @default.
- W2945642997 cites W2767861993 @default.
- W2945642997 cites W2769847562 @default.
- W2945642997 cites W2769873734 @default.
- W2945642997 cites W2770003411 @default.
- W2945642997 cites W2770726982 @default.
- W2945642997 cites W2771016236 @default.
- W2945642997 cites W2774655394 @default.
- W2945642997 cites W2775776733 @default.
- W2945642997 cites W2782767753 @default.
- W2945642997 cites W2782834515 @default.
- W2945642997 cites W2783431019 @default.
- W2945642997 cites W2790040397 @default.
- W2945642997 cites W2790925274 @default.
- W2945642997 cites W2792558334 @default.
- W2945642997 cites W2792829239 @default.
- W2945642997 cites W2793664782 @default.
- W2945642997 cites W2795084638 @default.
- W2945642997 cites W2802146191 @default.
- W2945642997 cites W2803752613 @default.
- W2945642997 cites W2805672969 @default.
- W2945642997 cites W2805747866 @default.
- W2945642997 cites W2808190774 @default.
- W2945642997 cites W2811181004 @default.