Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945643775> ?p ?o ?g. }
- W2945643775 endingPage "2369" @default.
- W2945643775 startingPage "2369" @default.
- W2945643775 abstract "Kombucha tea (KT) has emerged as a substance that protects the liver from damage; however, its mechanisms of action on the fatty liver remain unclear. Therefore, we investigated the potential role of KT and its underlying mechanisms on nonalcoholic fatty liver disease (NAFLD). db/db mice that were fed methionine/choline-deficient (MCD) diets for seven weeks were treated for vehicle (M + V) or KT (M + K) and fed with MCD for four additional weeks. Histomorphological injury and increased levels of liver enzymes and lipids were evident in the M + V group, whereas these symptoms were ameliorated in the M + K group. The M + K group had more proliferating and less apoptotic hepatocytic cells than the M + V group. Lipid uptake and lipogenesis significantly decreased, and free fatty acid (FFA) oxidation increased in the M + K, when compared with the M + V group. With the reduction of hedgehog signaling, inflammation and fibrosis also declined in the M + K group. Palmitate (PA) treatment increased the accumulation of lipid droplets and decreased the viability of primary hepatocytes, whereas KT suppressed PA-induced damage in these cells by enhancing intracellular lipid disposal. These results suggest that KT protects hepatocytes from lipid toxicity by influencing the lipid metabolism, and it attenuates inflammation and fibrosis, which contributes to liver restoration in mice with NAFLD." @default.
- W2945643775 created "2019-05-29" @default.
- W2945643775 creator A5015827292 @default.
- W2945643775 creator A5025007605 @default.
- W2945643775 creator A5034345010 @default.
- W2945643775 creator A5037865378 @default.
- W2945643775 creator A5039324828 @default.
- W2945643775 creator A5048224243 @default.
- W2945643775 creator A5050704650 @default.
- W2945643775 creator A5058973542 @default.
- W2945643775 date "2019-05-13" @default.
- W2945643775 modified "2023-10-16" @default.
- W2945643775 title "Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis" @default.
- W2945643775 cites W1523155649 @default.
- W2945643775 cites W1558416547 @default.
- W2945643775 cites W1578250568 @default.
- W2945643775 cites W1740567524 @default.
- W2945643775 cites W1963533730 @default.
- W2945643775 cites W1964572117 @default.
- W2945643775 cites W1965307211 @default.
- W2945643775 cites W1968872717 @default.
- W2945643775 cites W1969584616 @default.
- W2945643775 cites W1973978057 @default.
- W2945643775 cites W1974208182 @default.
- W2945643775 cites W1978045299 @default.
- W2945643775 cites W1979025809 @default.
- W2945643775 cites W1982578021 @default.
- W2945643775 cites W1984077928 @default.
- W2945643775 cites W1985903411 @default.
- W2945643775 cites W1996285993 @default.
- W2945643775 cites W1996837832 @default.
- W2945643775 cites W2006241936 @default.
- W2945643775 cites W2017025391 @default.
- W2945643775 cites W2021688906 @default.
- W2945643775 cites W2022121217 @default.
- W2945643775 cites W2027217600 @default.
- W2945643775 cites W2028754040 @default.
- W2945643775 cites W2032878070 @default.
- W2945643775 cites W2034188379 @default.
- W2945643775 cites W2037038225 @default.
- W2945643775 cites W2047438155 @default.
- W2945643775 cites W2054912517 @default.
- W2945643775 cites W2057410422 @default.
- W2945643775 cites W2061898236 @default.
- W2945643775 cites W2063266633 @default.
- W2945643775 cites W2068256034 @default.
- W2945643775 cites W2069993585 @default.
- W2945643775 cites W2071867050 @default.
- W2945643775 cites W2072362233 @default.
- W2945643775 cites W2074921121 @default.
- W2945643775 cites W2084382398 @default.
- W2945643775 cites W2084589154 @default.
- W2945643775 cites W2088929386 @default.
- W2945643775 cites W2092412521 @default.
- W2945643775 cites W2093824918 @default.
- W2945643775 cites W2096947328 @default.
- W2945643775 cites W2097165440 @default.
- W2945643775 cites W2104681338 @default.
- W2945643775 cites W2119625908 @default.
- W2945643775 cites W2127012454 @default.
- W2945643775 cites W2133884538 @default.
- W2945643775 cites W2135095267 @default.
- W2945643775 cites W2137506791 @default.
- W2945643775 cites W2140468731 @default.
- W2945643775 cites W2142225943 @default.
- W2945643775 cites W2143479226 @default.
- W2945643775 cites W2155794657 @default.
- W2945643775 cites W2163484250 @default.
- W2945643775 cites W2167213027 @default.
- W2945643775 cites W2256935472 @default.
- W2945643775 cites W2281483562 @default.
- W2945643775 cites W2283843704 @default.
- W2945643775 cites W2324257742 @default.
- W2945643775 cites W2401028390 @default.
- W2945643775 cites W2404036105 @default.
- W2945643775 cites W2418747138 @default.
- W2945643775 cites W2461975854 @default.
- W2945643775 cites W2550059110 @default.
- W2945643775 cites W2622166101 @default.
- W2945643775 cites W2770129291 @default.
- W2945643775 cites W4235609024 @default.
- W2945643775 doi "https://doi.org/10.3390/ijms20092369" @default.
- W2945643775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6539514" @default.
- W2945643775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31086120" @default.
- W2945643775 hasPublicationYear "2019" @default.
- W2945643775 type Work @default.
- W2945643775 sameAs 2945643775 @default.
- W2945643775 citedByCount "24" @default.
- W2945643775 countsByYear W29456437752020 @default.
- W2945643775 countsByYear W29456437752021 @default.
- W2945643775 countsByYear W29456437752022 @default.
- W2945643775 countsByYear W29456437752023 @default.
- W2945643775 crossrefType "journal-article" @default.
- W2945643775 hasAuthorship W2945643775A5015827292 @default.
- W2945643775 hasAuthorship W2945643775A5025007605 @default.
- W2945643775 hasAuthorship W2945643775A5034345010 @default.
- W2945643775 hasAuthorship W2945643775A5037865378 @default.
- W2945643775 hasAuthorship W2945643775A5039324828 @default.