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- W2945646497 endingPage "H275" @default.
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- W2945646497 abstract "Diabetes is a metabolic disorder characterized by hyperglycemia, resulting in low-grade systemic inflammation. Diabetic cardiomyopathy (DCM) is a common complication among diabetic patients, and the mechanism underlying its induction of cardiac remodeling and dysfunction remains unclear. Numerous experimental and clinical studies have suggested that adaptive immunity, especially T lymphocyte-mediated immunity, plays a potentially important role in the pathogenesis of diabetes and DCM. Metallothioneins (MTs), cysteine-rich, metal-binding proteins, have antioxidant properties. Some potential mechanisms underlying the cardioprotective effects of MTs include the role of MTs in calcium regulation, zinc homeostasis, insulin sensitization, and antioxidant activity. Moreover, metal homeostasis, especially MT-regulated zinc homeostasis, is essential for immune function. This review discusses aberrant immune regulation in diabetic heart disease with respect to endothelial insulin resistance and the effects of hyperglycemia and hyperlipidemia on tissues and the different effects of intracellular and extracellular MTs on adaptive immunity. This review shows that intracellular MTs are involved in naïve T-cell activation and reduce regulatory T-cell (Treg) polarization, whereas extracellular MTs promote proliferation and survival in naïve T cells and Treg polarization but inhibit their activation, thus revealing potential therapeutic strategies targeting the regulation of immune cell function by MTs." @default.
- W2945646497 created "2019-05-29" @default.
- W2945646497 creator A5010870618 @default.
- W2945646497 creator A5017873319 @default.
- W2945646497 creator A5021871011 @default.
- W2945646497 creator A5036233749 @default.
- W2945646497 date "2019-08-01" @default.
- W2945646497 modified "2023-10-17" @default.
- W2945646497 title "The adaptive immune role of metallothioneins in the pathogenesis of diabetic cardiomyopathy: good or bad" @default.
- W2945646497 cites W1536052747 @default.
- W2945646497 cites W1574329348 @default.
- W2945646497 cites W1661548638 @default.
- W2945646497 cites W1758183764 @default.
- W2945646497 cites W1931315964 @default.
- W2945646497 cites W1943607432 @default.
- W2945646497 cites W1965919540 @default.
- W2945646497 cites W1967539065 @default.
- W2945646497 cites W1971775177 @default.
- W2945646497 cites W1972480003 @default.
- W2945646497 cites W1974033843 @default.
- W2945646497 cites W1974067700 @default.
- W2945646497 cites W1983893679 @default.
- W2945646497 cites W1984996259 @default.
- W2945646497 cites W1985726538 @default.
- W2945646497 cites W1987060644 @default.
- W2945646497 cites W1991759958 @default.
- W2945646497 cites W1996268080 @default.
- W2945646497 cites W1997850644 @default.
- W2945646497 cites W1998414732 @default.
- W2945646497 cites W2002186423 @default.
- W2945646497 cites W2004524109 @default.
- W2945646497 cites W2004971151 @default.
- W2945646497 cites W2006544095 @default.
- W2945646497 cites W2007213846 @default.
- W2945646497 cites W2007865656 @default.
- W2945646497 cites W2007906514 @default.
- W2945646497 cites W2010484682 @default.
- W2945646497 cites W2011603566 @default.
- W2945646497 cites W2012348258 @default.
- W2945646497 cites W2013948741 @default.
- W2945646497 cites W2015542208 @default.
- W2945646497 cites W2017823004 @default.
- W2945646497 cites W2020253874 @default.
- W2945646497 cites W2024554599 @default.
- W2945646497 cites W2027150047 @default.
- W2945646497 cites W2033877575 @default.
- W2945646497 cites W2033946555 @default.
- W2945646497 cites W2035721892 @default.
- W2945646497 cites W2038257961 @default.
- W2945646497 cites W2038961236 @default.
- W2945646497 cites W2040216627 @default.
- W2945646497 cites W2044687165 @default.
- W2945646497 cites W2046864860 @default.
- W2945646497 cites W2048143404 @default.
- W2945646497 cites W2048936130 @default.
- W2945646497 cites W2053137491 @default.
- W2945646497 cites W2053638660 @default.
- W2945646497 cites W2054472394 @default.
- W2945646497 cites W2055700907 @default.
- W2945646497 cites W2056914993 @default.
- W2945646497 cites W2060817939 @default.
- W2945646497 cites W2064640660 @default.
- W2945646497 cites W2064752763 @default.
- W2945646497 cites W2065001185 @default.
- W2945646497 cites W2065210647 @default.
- W2945646497 cites W2067399169 @default.
- W2945646497 cites W2071885549 @default.
- W2945646497 cites W2079561811 @default.
- W2945646497 cites W2079983025 @default.
- W2945646497 cites W2080155677 @default.
- W2945646497 cites W2082960209 @default.
- W2945646497 cites W2083227337 @default.
- W2945646497 cites W2086581449 @default.
- W2945646497 cites W2090916216 @default.
- W2945646497 cites W2094285507 @default.
- W2945646497 cites W2095525101 @default.
- W2945646497 cites W2104679809 @default.
- W2945646497 cites W2108359388 @default.
- W2945646497 cites W2108547067 @default.
- W2945646497 cites W2108762011 @default.
- W2945646497 cites W2108891875 @default.
- W2945646497 cites W2110630395 @default.
- W2945646497 cites W2111268474 @default.
- W2945646497 cites W2114063557 @default.
- W2945646497 cites W2114646110 @default.
- W2945646497 cites W2117121624 @default.
- W2945646497 cites W2120317645 @default.
- W2945646497 cites W2126658199 @default.
- W2945646497 cites W2129991688 @default.
- W2945646497 cites W2132557486 @default.
- W2945646497 cites W2135140753 @default.
- W2945646497 cites W2135378280 @default.
- W2945646497 cites W2135647797 @default.
- W2945646497 cites W2138816083 @default.
- W2945646497 cites W2139419196 @default.
- W2945646497 cites W2141103901 @default.
- W2945646497 cites W2141706093 @default.
- W2945646497 cites W2145478166 @default.