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- W2945654734 endingPage "534" @default.
- W2945654734 startingPage "515" @default.
- W2945654734 abstract "PI3Ks are a family of lipid kinases that phosphorylate intracellular inositol lipids to regulate signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided into three classes. The class I PI3Ks generate 3-phosphoinositide lipids, which directly activate signal transduction pathways. In addition to being frequently genetically activated in cancer, similar mutations in class I PI3Ks have now also been found in a human non-malignant overgrowth syndrome and a primary immune disorder that predisposes to lymphoma. The class II and class III PI3Ks are regulators of membrane traffic along the endocytic route, in endosomal recycling and autophagy, with an often indirect effect on cell signalling. Here, we summarize current knowledge of the different PI3K classes and isoforms, focusing on recently uncovered biological functions and the mechanisms by which these kinases are activated. Deeper insight into the PI3K isoforms will undoubtedly continue to contribute to a better understanding of fundamental cell biological processes and, ultimately, of human disease. Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that generate 3-phosphoinositides, which govern cellular signal transduction and membrane trafficking. The PI3K family comprises three classes of enzymes, which include several isoforms and complexes; the myriad of cellular functions and means of regulation of these enzymes are now coming into focus." @default.
- W2945654734 created "2019-05-29" @default.
- W2945654734 creator A5013719000 @default.
- W2945654734 creator A5015185550 @default.
- W2945654734 creator A5051010078 @default.
- W2945654734 date "2019-05-20" @default.
- W2945654734 modified "2023-10-11" @default.
- W2945654734 title "PI3K isoforms in cell signalling and vesicle trafficking" @default.
- W2945654734 cites W1254214770 @default.
- W2945654734 cites W1486786974 @default.
- W2945654734 cites W1524785967 @default.
- W2945654734 cites W1538845089 @default.
- W2945654734 cites W1550997731 @default.
- W2945654734 cites W1840193836 @default.
- W2945654734 cites W1943203070 @default.
- W2945654734 cites W1957642752 @default.
- W2945654734 cites W1966533220 @default.
- W2945654734 cites W1966828940 @default.
- W2945654734 cites W1967224800 @default.
- W2945654734 cites W1967976750 @default.
- W2945654734 cites W1968513003 @default.
- W2945654734 cites W1971525986 @default.
- W2945654734 cites W1974128502 @default.
- W2945654734 cites W1975612877 @default.
- W2945654734 cites W1976040992 @default.
- W2945654734 cites W1977701732 @default.
- W2945654734 cites W1979237890 @default.
- W2945654734 cites W1980040544 @default.
- W2945654734 cites W1984453879 @default.
- W2945654734 cites W1984642820 @default.
- W2945654734 cites W1986744874 @default.
- W2945654734 cites W1990450608 @default.
- W2945654734 cites W1992477322 @default.
- W2945654734 cites W1992517740 @default.
- W2945654734 cites W1993142500 @default.
- W2945654734 cites W1996021619 @default.
- W2945654734 cites W1996222881 @default.
- W2945654734 cites W1999211990 @default.
- W2945654734 cites W1999662139 @default.
- W2945654734 cites W2002717894 @default.
- W2945654734 cites W2003968071 @default.
- W2945654734 cites W2012549345 @default.
- W2945654734 cites W2013544053 @default.
- W2945654734 cites W2013958792 @default.
- W2945654734 cites W2017214527 @default.
- W2945654734 cites W2018343427 @default.
- W2945654734 cites W2023525322 @default.
- W2945654734 cites W2025457067 @default.
- W2945654734 cites W2025891519 @default.
- W2945654734 cites W2027239007 @default.
- W2945654734 cites W2027601065 @default.
- W2945654734 cites W2028549997 @default.
- W2945654734 cites W2029066126 @default.
- W2945654734 cites W2031918765 @default.
- W2945654734 cites W2033280710 @default.
- W2945654734 cites W2033999408 @default.
- W2945654734 cites W2034623756 @default.
- W2945654734 cites W2034691869 @default.
- W2945654734 cites W2038641650 @default.
- W2945654734 cites W2041608775 @default.
- W2945654734 cites W2045616300 @default.
- W2945654734 cites W2046584993 @default.
- W2945654734 cites W2049173806 @default.
- W2945654734 cites W2050346490 @default.
- W2945654734 cites W2050539911 @default.
- W2945654734 cites W2052618262 @default.
- W2945654734 cites W2053073281 @default.
- W2945654734 cites W2053981201 @default.
- W2945654734 cites W2054917860 @default.
- W2945654734 cites W2055630249 @default.
- W2945654734 cites W2055698355 @default.
- W2945654734 cites W2057370954 @default.
- W2945654734 cites W2059259875 @default.
- W2945654734 cites W2059348339 @default.
- W2945654734 cites W2059776825 @default.
- W2945654734 cites W2062464922 @default.
- W2945654734 cites W2063569450 @default.
- W2945654734 cites W2065187811 @default.
- W2945654734 cites W2067019627 @default.
- W2945654734 cites W2067394226 @default.
- W2945654734 cites W2068547048 @default.
- W2945654734 cites W2069648181 @default.
- W2945654734 cites W2072765132 @default.
- W2945654734 cites W2073057670 @default.
- W2945654734 cites W2073100248 @default.
- W2945654734 cites W2075486945 @default.
- W2945654734 cites W2077422609 @default.
- W2945654734 cites W2081143487 @default.
- W2945654734 cites W2081920342 @default.
- W2945654734 cites W2089354038 @default.
- W2945654734 cites W2093882277 @default.
- W2945654734 cites W2094231976 @default.
- W2945654734 cites W2095861825 @default.
- W2945654734 cites W2097148290 @default.
- W2945654734 cites W2100288916 @default.
- W2945654734 cites W2102004296 @default.
- W2945654734 cites W2102886820 @default.
- W2945654734 cites W2105012660 @default.