FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945657384> ?p ?o ?g. }

• W2945657384 endingPage "17311" @default.
• W2945657384 startingPage "17303" @default.
• W2945657384 abstract "Abstract SR splicing‐factors (SRSFs) play a vital role in carcinogenesis. SRSF5 was demonstrated to be upregulated in lung cancer and identified as a novel prognostic indicator for small‐cell lung cancer. However, the role of SRSF5 in the pathogenesis of non–small cell lung cancer (NSCLC) and the molecular mechanism involved are still undefined. The expression of SRSF5 in NSCLC cells was detected by quantitative real‐time polymerase chain reaction and Western blot analysis. The proliferation of cells was evaluated by cell counting kit‐8 and BrdU assays. Apoptosis was assessed by flow cytometry and Western blot analysis of apoptosis‐associated proteins including B‐cell lymphoma 2 (Bcl‐2), Bax, and cytochrome C (Cyt C). Glycolysis was detected by determining glucose consumption, lactate production, and pyruvate kinase M2 (PKM2) expression. We found that SRSF5 messenger RNA and protein levels were elevated in NSCLC cells. SRSF5 knockdown inhibited the proliferation and Ki67 expression in NSCLC cells. SRSF5 silencing increased the apoptotic rate, upregulated Bax and Cyt C, and decreased Bcl‐2 level in NSCLC cells. Moreover, Knockdown of SRSF5 repressed glycolysis in NSCLC cells via reducing PKM2 expression. Enhanced glycolysis by PKM2 overexpression attenuated the effects of SRSF5 silencing on NSCLC cell proliferation and apoptosis. Overall, knockdown of SRSF5 inhibited proliferative ability and induced apoptosis by suppressing PKM2 expression in NSCLC cells." @default.
• W2945657384 created "2019-05-29" @default.
• W2945657384 creator A5001138849 @default.
• W2945657384 creator A5019553571 @default.
• W2945657384 creator A5020782783 @default.
• W2945657384 creator A5067922544 @default.
• W2945657384 creator A5071657495 @default.
• W2945657384 date "2019-05-20" @default.
• W2945657384 modified "2023-10-15" @default.
• W2945657384 title "Antitumor activity of SR splicing‐factor 5 knockdown by downregulating pyruvate kinase M2 in non–small cell lung cancer cells" @default.
• W2945657384 cites W1878175360 @default.
• W2945657384 cites W1969213466 @default.
• W2945657384 cites W1970108031 @default.
• W2945657384 cites W1970615527 @default.
• W2945657384 cites W1978574124 @default.
• W2945657384 cites W1984146948 @default.
• W2945657384 cites W1984633753 @default.
• W2945657384 cites W1989336986 @default.
• W2945657384 cites W1989734503 @default.
• W2945657384 cites W2019606904 @default.
• W2945657384 cites W2026657651 @default.
• W2945657384 cites W2027598957 @default.
• W2945657384 cites W2029363740 @default.
• W2945657384 cites W2066687597 @default.
• W2945657384 cites W2073595824 @default.
• W2945657384 cites W2105665764 @default.
• W2945657384 cites W2105899567 @default.
• W2945657384 cites W2115675218 @default.
• W2945657384 cites W2117692326 @default.
• W2945657384 cites W2135743020 @default.
• W2945657384 cites W2149929401 @default.
• W2945657384 cites W2197459998 @default.
• W2945657384 cites W2272984102 @default.
• W2945657384 cites W2399067949 @default.
• W2945657384 cites W2417759336 @default.
• W2945657384 cites W2590894935 @default.
• W2945657384 cites W2806026562 @default.
• W2945657384 cites W2809438292 @default.
• W2945657384 doi "https://doi.org/10.1002/jcb.28992" @default.
• W2945657384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31106485" @default.
• W2945657384 hasPublicationYear "2019" @default.
• W2945657384 type Work @default.
• W2945657384 sameAs 2945657384 @default.
• W2945657384 citedByCount "9" @default.
• W2945657384 countsByYear W29456573842021 @default.
• W2945657384 countsByYear W29456573842022 @default.
• W2945657384 countsByYear W29456573842023 @default.
• W2945657384 crossrefType "journal-article" @default.
• W2945657384 hasAuthorship W2945657384A5001138849 @default.
• W2945657384 hasAuthorship W2945657384A5019553571 @default.
• W2945657384 hasAuthorship W2945657384A5020782783 @default.
• W2945657384 hasAuthorship W2945657384A5067922544 @default.
• W2945657384 hasAuthorship W2945657384A5071657495 @default.
• W2945657384 hasConcept C104317684 @default.
• W2945657384 hasConcept C10730799 @default.
• W2945657384 hasConcept C119056186 @default.
• W2945657384 hasConcept C121608353 @default.
• W2945657384 hasConcept C127561419 @default.
• W2945657384 hasConcept C153911025 @default.
• W2945657384 hasConcept C173396325 @default.
• W2945657384 hasConcept C181199279 @default.
• W2945657384 hasConcept C185592680 @default.
• W2945657384 hasConcept C190283241 @default.
• W2945657384 hasConcept C20251656 @default.
• W2945657384 hasConcept C2780854706 @default.
• W2945657384 hasConcept C502942594 @default.
• W2945657384 hasConcept C54355233 @default.
• W2945657384 hasConcept C55493867 @default.
• W2945657384 hasConcept C555283112 @default.
• W2945657384 hasConcept C62112901 @default.
• W2945657384 hasConcept C86803240 @default.
• W2945657384 hasConceptScore W2945657384C104317684 @default.
• W2945657384 hasConceptScore W2945657384C10730799 @default.
• W2945657384 hasConceptScore W2945657384C119056186 @default.
• W2945657384 hasConceptScore W2945657384C121608353 @default.
• W2945657384 hasConceptScore W2945657384C127561419 @default.
• W2945657384 hasConceptScore W2945657384C153911025 @default.
• W2945657384 hasConceptScore W2945657384C173396325 @default.
• W2945657384 hasConceptScore W2945657384C181199279 @default.
• W2945657384 hasConceptScore W2945657384C185592680 @default.
• W2945657384 hasConceptScore W2945657384C190283241 @default.
• W2945657384 hasConceptScore W2945657384C20251656 @default.
• W2945657384 hasConceptScore W2945657384C2780854706 @default.
• W2945657384 hasConceptScore W2945657384C502942594 @default.
• W2945657384 hasConceptScore W2945657384C54355233 @default.
• W2945657384 hasConceptScore W2945657384C55493867 @default.
• W2945657384 hasConceptScore W2945657384C555283112 @default.
• W2945657384 hasConceptScore W2945657384C62112901 @default.
• W2945657384 hasConceptScore W2945657384C86803240 @default.
• W2945657384 hasIssue "10" @default.
• W2945657384 hasLocation W29456573841 @default.
• W2945657384 hasLocation W29456573842 @default.
• W2945657384 hasOpenAccess W2945657384 @default.
• W2945657384 hasPrimaryLocation W29456573841 @default.
• W2945657384 hasRelatedWork W2017788809 @default.
• W2945657384 hasRelatedWork W2041761948 @default.
• W2945657384 hasRelatedWork W2047697966 @default.
• W2945657384 hasRelatedWork W2058516587 @default.

• next