FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945658156> ?p ?o ?g. }

• W2945658156 endingPage "1166" @default.
• W2945658156 startingPage "1160" @default.
• W2945658156 abstract "High glucose (HG)-caused damage of retinal ganglion cells (RGCs) plays an important role in the pathogenesis of diabetic retinopathy, a common and severe complication of diabetes mellitus. Accumulating evidence has reported that brahma-related gene 1 (Brg1) exerts a cytoprotective role in protection of cells from various injuries. In this study, we investigated the role of Brg1 in regulating HG-induced injury of RGCs. We found that RGCs treated with HG exhibited a low expression level of Brg1 compared with untreated RGCs. Gain-of-function experiments showed that Brg1 overexpression significantly improved the viability and reduced the apoptosis of RGCs exposed to HG. Notably, our data revealed that Brg1 overexpression increased the expression of Notch ligands, including Jagged 1, Jagged 2, Delta-like 1, and Delta-like 4. Moreover, Brg1 overexpression upregulated the expression of Notch1 intracellular domain (NICD) and Hes1, which resulted in activation of Notch signaling. Blockade of Notch signaling partially reversed Brg1-mediated protection effect in HG-treated RGCs, while overexpression of NICD significantly attenuated the promotion effect of Brg1 silencing on HG-induced injury in RGCs. Taken together, these results suggest that Brg1 protects RGCs against HG-induced injury through enhancing the activation of Notch signaling, suggesting a potential target for preserving RGCs in diabetic retinopathy." @default.
• W2945658156 created "2019-05-29" @default.
• W2945658156 creator A5009761511 @default.
• W2945658156 creator A5028721700 @default.
• W2945658156 creator A5049959303 @default.
• W2945658156 creator A5064065903 @default.
• W2945658156 date "2019-07-01" @default.
• W2945658156 modified "2023-10-01" @default.
• W2945658156 title "Overexpression of Brg1 alleviates high glucose-induced retinal ganglion cell apoptosis though regulating Notch/Hes1 signaling" @default.
• W2945658156 cites W1811355798 @default.
• W2945658156 cites W1989840336 @default.
• W2945658156 cites W2003724153 @default.
• W2945658156 cites W2039620484 @default.
• W2945658156 cites W2044858838 @default.
• W2945658156 cites W2049594614 @default.
• W2945658156 cites W2050388131 @default.
• W2945658156 cites W2079793058 @default.
• W2945658156 cites W2111504520 @default.
• W2945658156 cites W2128591799 @default.
• W2945658156 cites W2162377737 @default.
• W2945658156 cites W2295616444 @default.
• W2945658156 cites W2327433548 @default.
• W2945658156 cites W2488406488 @default.
• W2945658156 cites W2501416242 @default.
• W2945658156 cites W2506273806 @default.
• W2945658156 cites W2614778484 @default.
• W2945658156 cites W2617640978 @default.
• W2945658156 cites W2620692477 @default.
• W2945658156 cites W2740510276 @default.
• W2945658156 cites W2744829308 @default.
• W2945658156 cites W2747415004 @default.
• W2945658156 cites W2789297171 @default.
• W2945658156 cites W2884186955 @default.
• W2945658156 cites W2891431381 @default.
• W2945658156 cites W2894624448 @default.
• W2945658156 cites W4254778823 @default.
• W2945658156 cites W4294349352 @default.
• W2945658156 doi "https://doi.org/10.1016/j.bbrc.2019.05.069" @default.
• W2945658156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31101335" @default.
• W2945658156 hasPublicationYear "2019" @default.
• W2945658156 type Work @default.
• W2945658156 sameAs 2945658156 @default.
• W2945658156 citedByCount "11" @default.
• W2945658156 countsByYear W29456581562019 @default.
• W2945658156 countsByYear W29456581562020 @default.
• W2945658156 countsByYear W29456581562021 @default.
• W2945658156 countsByYear W29456581562022 @default.
• W2945658156 countsByYear W29456581562023 @default.
• W2945658156 crossrefType "journal-article" @default.
• W2945658156 hasAuthorship W2945658156A5009761511 @default.
• W2945658156 hasAuthorship W2945658156A5028721700 @default.
• W2945658156 hasAuthorship W2945658156A5049959303 @default.
• W2945658156 hasAuthorship W2945658156A5064065903 @default.
• W2945658156 hasConcept C104317684 @default.
• W2945658156 hasConcept C126322002 @default.
• W2945658156 hasConcept C127561419 @default.
• W2945658156 hasConcept C134018914 @default.
• W2945658156 hasConcept C161879069 @default.
• W2945658156 hasConcept C185592680 @default.
• W2945658156 hasConcept C190283241 @default.
• W2945658156 hasConcept C2779829184 @default.
• W2945658156 hasConcept C2780283210 @default.
• W2945658156 hasConcept C2780942790 @default.
• W2945658156 hasConcept C502942594 @default.
• W2945658156 hasConcept C55493867 @default.
• W2945658156 hasConcept C555293320 @default.
• W2945658156 hasConcept C62478195 @default.
• W2945658156 hasConcept C71924100 @default.
• W2945658156 hasConcept C86803240 @default.
• W2945658156 hasConcept C95444343 @default.
• W2945658156 hasConceptScore W2945658156C104317684 @default.
• W2945658156 hasConceptScore W2945658156C126322002 @default.
• W2945658156 hasConceptScore W2945658156C127561419 @default.
• W2945658156 hasConceptScore W2945658156C134018914 @default.
• W2945658156 hasConceptScore W2945658156C161879069 @default.
• W2945658156 hasConceptScore W2945658156C185592680 @default.
• W2945658156 hasConceptScore W2945658156C190283241 @default.
• W2945658156 hasConceptScore W2945658156C2779829184 @default.
• W2945658156 hasConceptScore W2945658156C2780283210 @default.
• W2945658156 hasConceptScore W2945658156C2780942790 @default.
• W2945658156 hasConceptScore W2945658156C502942594 @default.
• W2945658156 hasConceptScore W2945658156C55493867 @default.
• W2945658156 hasConceptScore W2945658156C555293320 @default.
• W2945658156 hasConceptScore W2945658156C62478195 @default.
• W2945658156 hasConceptScore W2945658156C71924100 @default.
• W2945658156 hasConceptScore W2945658156C86803240 @default.
• W2945658156 hasConceptScore W2945658156C95444343 @default.
• W2945658156 hasIssue "4" @default.
• W2945658156 hasLocation W29456581561 @default.
• W2945658156 hasLocation W29456581562 @default.
• W2945658156 hasOpenAccess W2945658156 @default.
• W2945658156 hasPrimaryLocation W29456581561 @default.
• W2945658156 hasRelatedWork W1978215356 @default.
• W2945658156 hasRelatedWork W1990534862 @default.
• W2945658156 hasRelatedWork W2059330780 @default.
• W2945658156 hasRelatedWork W2093425923 @default.
• W2945658156 hasRelatedWork W2119839245 @default.
• W2945658156 hasRelatedWork W2379182815 @default.

• next