Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945659433> ?p ?o ?g. }
- W2945659433 endingPage "175628641985140" @default.
- W2945659433 startingPage "175628641985140" @default.
- W2945659433 abstract "Parkinson's disease (PD) is a highly heterogeneous clinical entity. Patients with young-onset PD (YOPD) show some characteristic manifestations to late-onset PD (LOPD). The current study aimed to investigate the cerebral dopaminergic and metabolic characteristics in YOPD with positron emission tomography (PET) imaging. In our study, 103 subjects (42 YOPD and 61 LOPD patients) accepted both 11C-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane (11C-CFT) and 18F-fluorodeoxyglucose (18F-FDG) cerebral PET imaging. Sixty-two patients out of 103 patients in our study completed the cognition tests. In this limited subsection, YOPD patients performed better in cognitive functioning than LOPD patients of similar disease duration. In 11C-CFT imaging, dopamine transporter binding in caudate was relatively spared in YOPD compared with lesions in putamen. In 18F-FDG PET, YOPD patients showed increased metabolism in basal ganglia relative to the healthy controls. When compared with LOPD patients, YOPD patients exhibited hypermetabolism in caudate and hypometabolism in putamen. Furthermore, the regional metabolic values in caudate correlated positively and moderately with the dopaminergic binding deficiency in caudate. The findings of this imaging study might offer new perspectives in understanding the characteristic manifestations in YOPD in light of better-preserved cognition function." @default.
- W2945659433 created "2019-05-29" @default.
- W2945659433 creator A5001118110 @default.
- W2945659433 creator A5023521085 @default.
- W2945659433 creator A5040589320 @default.
- W2945659433 creator A5046597600 @default.
- W2945659433 creator A5059231948 @default.
- W2945659433 creator A5062014421 @default.
- W2945659433 creator A5067904400 @default.
- W2945659433 creator A5071247794 @default.
- W2945659433 creator A5079711772 @default.
- W2945659433 date "2019-01-01" @default.
- W2945659433 modified "2023-10-12" @default.
- W2945659433 title "Preserved caudate function in young-onset patients with Parkinson’s disease: a dual-tracer PET imaging study" @default.
- W2945659433 cites W1533056363 @default.
- W2945659433 cites W1827708574 @default.
- W2945659433 cites W1889522154 @default.
- W2945659433 cites W1900092052 @default.
- W2945659433 cites W1967035747 @default.
- W2945659433 cites W1982535961 @default.
- W2945659433 cites W1986509325 @default.
- W2945659433 cites W1988440986 @default.
- W2945659433 cites W1990115112 @default.
- W2945659433 cites W1991304179 @default.
- W2945659433 cites W1997195117 @default.
- W2945659433 cites W1998896287 @default.
- W2945659433 cites W2008139594 @default.
- W2945659433 cites W2020536810 @default.
- W2945659433 cites W2023390230 @default.
- W2945659433 cites W2046077833 @default.
- W2945659433 cites W2051526293 @default.
- W2945659433 cites W2052152078 @default.
- W2945659433 cites W2054462180 @default.
- W2945659433 cites W2059999696 @default.
- W2945659433 cites W2070003162 @default.
- W2945659433 cites W2074302943 @default.
- W2945659433 cites W2084699362 @default.
- W2945659433 cites W2092462980 @default.
- W2945659433 cites W2095377833 @default.
- W2945659433 cites W2107162803 @default.
- W2945659433 cites W2112581313 @default.
- W2945659433 cites W2115116088 @default.
- W2945659433 cites W2117057382 @default.
- W2945659433 cites W2117277050 @default.
- W2945659433 cites W2118163650 @default.
- W2945659433 cites W2121275558 @default.
- W2945659433 cites W2129697505 @default.
- W2945659433 cites W2132881915 @default.
- W2945659433 cites W2134128653 @default.
- W2945659433 cites W2148992333 @default.
- W2945659433 cites W2152316935 @default.
- W2945659433 cites W2156013560 @default.
- W2945659433 cites W2163144163 @default.
- W2945659433 cites W2164028779 @default.
- W2945659433 cites W2272581670 @default.
- W2945659433 cites W2571918371 @default.
- W2945659433 cites W2789732377 @default.
- W2945659433 cites W2806622175 @default.
- W2945659433 cites W2879894516 @default.
- W2945659433 doi "https://doi.org/10.1177/1756286419851400" @default.
- W2945659433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6535758" @default.
- W2945659433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31205495" @default.
- W2945659433 hasPublicationYear "2019" @default.
- W2945659433 type Work @default.
- W2945659433 sameAs 2945659433 @default.
- W2945659433 citedByCount "6" @default.
- W2945659433 countsByYear W29456594332021 @default.
- W2945659433 countsByYear W29456594332022 @default.
- W2945659433 countsByYear W29456594332023 @default.
- W2945659433 crossrefType "journal-article" @default.
- W2945659433 hasAuthorship W2945659433A5001118110 @default.
- W2945659433 hasAuthorship W2945659433A5023521085 @default.
- W2945659433 hasAuthorship W2945659433A5040589320 @default.
- W2945659433 hasAuthorship W2945659433A5046597600 @default.
- W2945659433 hasAuthorship W2945659433A5059231948 @default.
- W2945659433 hasAuthorship W2945659433A5062014421 @default.
- W2945659433 hasAuthorship W2945659433A5067904400 @default.
- W2945659433 hasAuthorship W2945659433A5071247794 @default.
- W2945659433 hasAuthorship W2945659433A5079711772 @default.
- W2945659433 hasBestOaLocation W29456594331 @default.
- W2945659433 hasConcept C10162356 @default.
- W2945659433 hasConcept C126322002 @default.
- W2945659433 hasConcept C137183658 @default.
- W2945659433 hasConcept C2775842073 @default.
- W2945659433 hasConcept C2776755682 @default.
- W2945659433 hasConcept C2777464067 @default.
- W2945659433 hasConcept C2778187257 @default.
- W2945659433 hasConcept C2779134260 @default.
- W2945659433 hasConcept C2779714222 @default.
- W2945659433 hasConcept C2779734285 @default.
- W2945659433 hasConcept C2781423529 @default.
- W2945659433 hasConcept C2989005 @default.
- W2945659433 hasConcept C513476851 @default.
- W2945659433 hasConcept C529278444 @default.
- W2945659433 hasConcept C71924100 @default.
- W2945659433 hasConceptScore W2945659433C10162356 @default.
- W2945659433 hasConceptScore W2945659433C126322002 @default.
- W2945659433 hasConceptScore W2945659433C137183658 @default.