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- W2945662712 abstract "We have infused DDAVP(1-desamino-8-D-arginine vasopressin)(0,4ug/Kg b.w.) in 15-20 min., during tooth extraction, in 1 patient(pt) with moderate hemophilia A,2 pts with classical von Willebrand’s disease(vWd), 1pt with vWd variant and 2 pts with FVIII+FV combined deficieney. At fixed times from infusion (0.15’,6h,24h)we have studied the behaviour of FVIII-related properties (VIII:C,VIIIR:AG,VIIIR:RCo). In every pt DDAVP increased all 3 FVIIT-relatcd properties, particularly the VIII:C augmented 4-5 fold the basal levels in the hemophilic and FVIII+FV deficiency pts, while it always reached the normal levels in vWd pts. In one of classical vWd pts, DDAVP permitted us to estimate the electrophoretic mobility(EM) of FVIII-related protein(undosable at 0 time by Laurell technique)which resulted normal, In the pt with vWd vari ant(C=7%, RCo < 5%, AG=100%, abnormal EM)the RCo reached only 18% and the EM always maintained abnormal. In the FVIII+FV deficiency pts the response of FVIII-related properties was similar to the hemophilic pt, while FV did not undergo any increase." @default.
- W2945662712 created "2019-05-29" @default.
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- W2945662712 date "1979-01-01" @default.
- W2945662712 modified "2023-09-23" @default.
- W2945662712 title "Behaviour of VIII—Related Properties in Response to Infusion of DDAVP in Patients With FVIII-Complex Disorders" @default.
- W2945662712 doi "https://doi.org/10.1055/s-0039-1687267" @default.
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